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Toxicol Sci

Title:		Editor's Highlight: Prospective Analyses of Volatile Organic Compounds in Obstructive Sleep Apnea Patients
Author(s):		Aoki T; Nagaoka T; Kobayashi N; Kurahashi M; Tsuji C; Takiguchi H; Tomomatsu K; Oguma T; Kobayashi N; Magatani K; Takeda S; Asano K; Abe T;
Address:		"Respiratory Division, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan. Waseda Research Institute for Science and Engineering, Waseda University, Shinjuku, Tokyo 169-8050, Japan. Ogino Memorial Laboratory, Nihon Kohden Corporation, Shinjuku, Tokyo 161-8560, Japan. Department of Physiology, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan. Department of Electrical and Electronic Engineering, Tokai University, Shonan, Kanagawa 259-1292, Japan. Department of Clinical Engineering, Tokyo University of Technology, Nishikamata, Tokyo 144-8535, Japan"
Journal Title:		Toxicol Sci
Year:		2017
Volume:		156
Issue:		2
Page Number:		362 - 374
DOI:		10.1093/toxsci/kfw260
ISSN/ISBN:		1096-0929 (Electronic) 1096-0929 (Linking)
Abstract:		"Various volatile organic compounds (VOCs) are known to be toxic. Although exhaled VOC patterns change in obstructive sleep apnea (OSA) patients, individual VOC profiles are not fully determined. The primary outcome was VOC characterizations; secondary outcomes included their relationships with sleep and clinical parameters in OSA patients. We prospectively examined 32 OSA patients with an apnea-hypopnea index (AHI) >/= 15 by full polysomnography, and 33 age- and sex-matched controls without obvious OSA symptoms. Nine severe OSA patients were examined before and after continuous positive airway pressure (CPAP) treatment. By applying a method which eliminates environmental VOC influences, exhaled VOCs were identified by gas chromatography (GC)-mass spectrometry, and their concentrations were determined by GC. Exhaled aromatic hydrocarbon concentrations (toluene, ethylbenzene, p-xylene, and phenylacetic acid) in the severe OSA groups (AHI >/= 30) and exhaled saturated hydrocarbon concentrations (hexane, heptane, octane, nonane, and decane) in the most severe OSA group (AHI >/= 60) were higher than those in the control group. Exhaled isoprene concentrations were increased in all OSA groups (AHI >/= 15); acetone concentration was increased in the most severe OSA group. Ethylbenzene, p-xylene, phenylacetic acid, and nonane concentrations were increased according to OSA severity, and correlated with AHI, arousal index, and duration of percutaneous oxygen saturation (SpO2)
Keywords:		"Case-Control Studies *Continuous Positive Airway Pressure Exhalation Gas Chromatography-Mass Spectrometry Humans Male Middle Aged Polysomnography Prospective Studies Regression Analysis Severity of Illness Index Sleep Apnea, Obstructive/diagnosis/*metabol;"
Notes:		"MedlineAoki, Takuya Nagaoka, Takashi Kobayashi, Naofumi Kurahashi, Muneshige Tsuji, Chizuko Takiguchi, Hiroto Tomomatsu, Katsuyoshi Oguma, Tsuyoshi Kobayashi, Naoki Magatani, Kazushige Takeda, Sunao Asano, Koichiro Abe, Tadashi eng Research Support, Non-U.S. Gov't 2016/12/23 Toxicol Sci. 2017 Apr 1; 156(2):362-374. doi: 10.1093/toxsci/kfw260"