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Int J Environ Res Public Health

Title:		"Changes in Biomarkers of Tobacco Exposure among Cigarette Smokers Transitioning to ENDS Use: The Population Assessment of Tobacco and Health Study, 2013-2015"
Author(s):		Anic GM; Rostron BL; Hammad HT; van Bemmel DM; Del Valle-Pinero AY; Christensen CH; Erives G; Faulcon LM; Blount BC; Wang Y; Wang L; Bhandari D; Calafat AM; Kimmel HL; Everard CD; Compton WM; Edwards KC; Goniewicz ML; Wei B; Hyland A; Hatsukami DK; Hecht SS; Niaura RS; Borek N; Ambrose BK; Chang CM;
Address:		"Office of Science, Center for Tobacco Products, Food and Drug Administration, Silver Spring, MD 20993, USA. Division of Laboratory Sciences, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA. National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD 20892, USA. Behavioral Health and Health Policy, Westat, Rockville, MD 20850, USA. Department of Health Behavior, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA. Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA. College of Global Public Health, New York University, New York, NY 10003, USA"
Journal Title:		Int J Environ Res Public Health
Year:		2022
Volume:		20220127
Issue:		3
Page Number:		-
DOI:		10.3390/ijerph19031462
ISSN/ISBN:		1660-4601 (Electronic) 1661-7827 (Print) 1660-4601 (Linking)
Abstract:		"Limited data are available for how biomarkers of tobacco exposure (BOE) change when cigarette smokers transition to using electronic nicotine delivery systems (ENDS). Using biomarker data from Waves 1 (2013-2014) and 2 (2014-2015) of the PATH Study, we examined how mean BOE concentrations, including metabolites of nicotine, tobacco-specific nitrosamines (TSNA), polycyclic aromatic hydrocarbons (PAH), and volatile organic compounds (VOC) and metals, changed when 2475 adult smokers transitioned to using ENDS or quit tobacco products. Exclusive smokers who transitioned to dual use had a significant decrease in NNAL (4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol), but not nicotine metabolites, most PAHs, metals, or VOCs. Exclusive smokers who became dual users had significant reductions in total nicotine equivalents, NNAL, and 2CyEMA (acrylonitrile metabolite), but only in those who reduced cigarettes per day (CPD) by >=50%. Smokers who transitioned to exclusive ENDS use had significant reductions in most TSNAs, PAHs, and VOCs; however, nicotine metabolites did not decrease in dual users who became exclusive ENDS users. Smokers who quit tobacco use had significant decreases in nicotine metabolites, all TSNAs, most PAHs, and most VOCs. Cigarette smokers who became dual users did not experience significant reductions in most BOEs. Reductions were impacted by changes in CPD. However, transitioning from smoking to no tobacco or exclusive ENDS use was associated with reduced exposure to most BOEs measured. Future analyses could incorporate additional waves of PATH data and examine changes in biomarker exposure by ENDS device type and CPD"
Keywords:		Adult Biomarkers/analysis *Electronic Nicotine Delivery Systems Humans Smokers Tobacco *Tobacco Products Tobacco Use biomarkers cigarettes e-cigarettes electronic nicotine delivery systems (ENDS);
Notes:		"MedlineAnic, Gabriella M Rostron, Brian L Hammad, Hoda T van Bemmel, Dana M Del Valle-Pinero, Arseima Y Christensen, Carol H Erives, Gladys Faulcon, Lisa M Blount, Benjamin C Wang, Yuesong Wang, Lanqing Bhandari, Deepak Calafat, Antonia M Kimmel, Heather L Everard, Colm D Compton, Wilson M Edwards, Kathryn C Goniewicz, Maciej L Wei, Binnian Hyland, Andrew Hatsukami, Dorothy K Hecht, Stephen S Niaura, Raymond S Borek, Nicolette Ambrose, Bridget K Chang, Cindy M eng P30 CA077598/CA/NCI NIH HHS/ HHSN271201100027C/DA/NIDA NIH HHS/ HHSN271201600001C/DA/NIDA NIH HHS/ Research Support, U.S. Gov't, P.H.S. Switzerland 2022/02/16 Int J Environ Res Public Health. 2022 Jan 27; 19(3):1462. doi: 10.3390/ijerph19031462"