| Title: | Novel aspects of pheromone-induced cell-cycle arrest in yeast |
| Address: | "Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA" |
| ISSN/ISBN: | 0172-8083 (Print) 0172-8083 (Linking) |
| Abstract: | "Saccharomyces cerevisiae responds to pheromones by arresting cell-cycle progression at the G1/S boundary. This arrest has been shown to require the activation by phosphorylation of Far1, a cyclin-dependent kinase inhibitor. Arrest resembling pheromone-induced arrest can be triggered by high levels of Ste12, the pheromone-responsive transcriptional activator. In the present study, cell-cycle arrest induced by high levels of Ste12 is characterized. This arrest occurs predominately at the G1/S boundary and is independent of Far1 and upstream components of the pheromone response pathway. Since Ste12 is a transcriptional activator, it is proposed that cell-cycle arrest in response to high levels of Ste12 is due to transcription of a Ste12-dependent arrest factor regulated primarily, but not necessarily exclusively, at the level of transcription. The data presented here suggest that a novel component has a role in arrest in response to pheromone" |
| Keywords: | Biological Factors/metabolism Cell Cycle/*physiology *Cell Cycle Proteins Cyclin-Dependent Kinase Inhibitor Proteins Diploidy Fungal Proteins/metabolism Kinetics Mating Factor Mutation Peptides/pharmacology Pheromones/pharmacology *Repressor Proteins Sacc; |
| Notes: | "MedlineDolan, J W eng 1996/12/01 Curr Genet. 1996 Dec; 30(6):469-75. doi: 10.1007/s002940050158" |
