| Title: | Cyclic Regulation of Sensory Perception by a Female Hormone Alters Behavior |
| Author(s): | Dey S; Chamero P; Pru JK; Chien MS; Ibarra-Soria X; Spencer KR; Logan DW; Matsunami H; Peluso JJ; Stowers L; |
| Address: | "Department of Molecular and Cellular Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA. Department of Physiology, University of Saarland School of Medicine, 66424 Homburg, Germany. The Center for Reproductive Biology, Department of Animal Science, Washington State University, Pullman, WA 99164, USA. Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA. Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK. Departments of Cell Biology and Obstetrics and Gynecology, University of Connecticut Health Center, Farmington, CT 06030, USA. Department of Molecular and Cellular Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: stowers@scripps.edu" |
| DOI: | 10.1016/j.cell.2015.04.052 |
| ISSN/ISBN: | 1097-4172 (Electronic) 0092-8674 (Print) 0092-8674 (Linking) |
| Abstract: | "Females may display dramatically different behavior depending on their state of ovulation. This is thought to occur through sex-specific hormones acting on behavioral centers in the brain. Whether incoming sensory activity also differs across the ovulation cycle to alter behavior has not been investigated. Here, we show that female mouse vomeronasal sensory neurons (VSNs) are temporarily and specifically rendered 'blind' to a subset of male-emitted pheromone ligands during diestrus yet fully detect and respond to the same ligands during estrus. VSN silencing occurs through the action of the female sex-steroid progesterone. Not all VSNs are targeted for silencing; those detecting cat ligands remain continuously active irrespective of the estrous state. We identify the signaling components that account for the capacity of progesterone to target specific subsets of male-pheromone responsive neurons for inactivation. These findings indicate that internal physiology can selectively and directly modulate sensory input to produce state-specific behavior. PAPERCLIP" |
| Keywords: | "Animals *Estrous Cycle Female Male Mice/*physiology Mice, Inbred C57BL Neurons/physiology Pheromones/metabolism Progesterone/metabolism Proteins/chemistry Sex Characteristics *Sexual Behavior, Animal *Smell Vomeronasal Organ/cytology/*physiology;neuroscience;" |
| Notes: | "MedlineDey, Sandeepa Chamero, Pablo Pru, James K Chien, Ming-Shan Ibarra-Soria, Ximena Spencer, Kathryn R Logan, Darren W Matsunami, Hiroaki Peluso, John J Stowers, Lisa eng DC009413/DC/NIDCD NIH HHS/ T32 HD040372/HD/NICHD NIH HHS/ T32 GM007754/GM/NIGMS NIH HHS/ R01 DC009413/DC/NIDCD NIH HHS/ R01 DC012095/DC/NIDCD NIH HHS/ R01 DC006885/DC/NIDCD NIH HHS/ DC010857/DC/NIDCD NIH HHS/ R01 DC010857/DC/NIDCD NIH HHS/ WT_/Wellcome Trust/United Kingdom R21 RR030264/RR/NCRR NIH HHS/ DC012095/DC/NIDCD NIH HHS/ DC006885/DC/NIDCD NIH HHS/ 098051/WT_/Wellcome Trust/United Kingdom Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't 2015/06/06 Cell. 2015 Jun 4; 161(6):1334-44. doi: 10.1016/j.cell.2015.04.052" |
