| Title: | Identification and quantification of glue-like off-odors in elastic therapeutic tapes |
| Address: | "Emil Fisher Center, Department of Chemistry and Pharmacy, Friedrich-Alexander-Universitat Erlangen-Nurnberg, Henkestrasse 9, 91054, Erlangen, Germany. Department Sensory Analytics, Fraunhofer Institute for Process Engineering and Packaging, Giggenhauser Strasse 35, 85354, Freising, Germany. Emil Fisher Center, Department of Chemistry and Pharmacy, Friedrich-Alexander-Universitat Erlangen-Nurnberg, Henkestrasse 9, 91054, Erlangen, Germany. andrea.buettner@ivv.fraunhofer.de. Department Sensory Analytics, Fraunhofer Institute for Process Engineering and Packaging, Giggenhauser Strasse 35, 85354, Freising, Germany. andrea.buettner@ivv.fraunhofer.de" |
| DOI: | 10.1007/s00216-018-1046-2 |
| ISSN/ISBN: | 1618-2650 (Electronic) 1618-2642 (Linking) |
| Abstract: | "Elastic therapeutic tapes are an important tool in the field of physical therapy and medicine. These tapes contain types of adhesive. However, sensory evaluations revealed the release of pronounced and irritating odors of the tapes. Negative odors were, amongst others, reported in elastic therapeutic tapes containing acrylic adhesives. In this study, the odor of four different tape samples was evaluated applying a descriptive analysis approach carried out by a trained sensory panel. Afterwards, the volatile compounds were recovered from the samples by solvent extraction and isolated by solvent-assisted flavor evaporation (SAFE). The obtained distillates were subsequently analyzed by gas chromatography-olfactometry (GC-O) and two-dimensional GC-O coupled with mass spectrometry (2D-GC-MS/O). To determine the most potent odorants in the distillates, odor extract dilution analyses (OEDA) were carried out. Thirty-one odorants were successfully identified using this approach, which were all described for the first time as odorants in tapes. Amongst the set of volatiles, unsaturated and saturated aldehydes were present, eliciting fatty, soapy, and citrus-like odor impressions, as well as a range of glue-like, moldy, and fruity smelling odor-active volatiles, such as 2-ethyl-1-hexanol, butyl benzoate, and 3-phenyltoluene. Based on their relative intensities, the concentrations of the glue-like smelling substances were determined: 2-ethyl-1-hexanol, present in all samples, was determined with concentrations ranging from 10 to 200 mg/kg in the investigated tapes" |
| Keywords: | Adhesives/*chemistry Aldehydes/*analysis Gas Chromatography-Mass Spectrometry/methods Hexanols/*analysis Humans Odorants/*analysis Olfactometry/methods Physical Therapy Modalities Volatile Organic Compounds/*analysis 2-Ethyl-1-hexanol Elastic therapeutic; |
| Notes: | "MedlineDenk, Philipp Buettner, Andrea eng Germany 2018/04/07 Anal Bioanal Chem. 2018 May; 410(14):3395-3404. doi: 10.1007/s00216-018-1046-2. Epub 2018 Apr 6" |
