| Title: | Breathprints of childhood obesity: changes in volatile organic compounds in obese children compared with lean controls |
| Author(s): | Alkhouri N; Eng K; Cikach F; Patel N; Yan C; Brindle A; Rome E; Hanouneh I; Grove D; Lopez R; Hazen SL; Dweik RA; |
| Address: | "Department of Pediatric Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, OH, USA; Digestive Disease Institute, Cleveland Clinic, Cleveland, OH, USA; Center for Cardiovascular Diagnostics and Prevention, Cleveland Clinic, Cleveland, OH, USA" |
| DOI: | 10.1111/j.2047-6310.2014.221.x |
| ISSN/ISBN: | 2047-6310 (Electronic) 2047-6302 (Print) 2047-6302 (Linking) |
| Abstract: | "OBJECTIVE: The objective of this study was to investigate changes in volatile organic compounds (VOCs) in exhaled breath in overweight/obese children compared with their lean counterparts. STUDY DESIGN: Single exhaled breath was collected and analyzed per protocol using selective ion flow tube mass spectrometry (SIFT-MS). RESULTS: Sixty overweight/obese children and 55 lean controls were included. Compared with the lean group, the obese group was significantly older (14.1 +/- 2.8 vs. 12.1 +/- 3.0 years), taller (164.8 +/- 10.9 vs. 153.3 +/- 17.1 cm) and more likely to be Caucasian (60% vs. 35.2%); P < 0.05 for all. A comparison of the SIFT-MS results of the obese group with the lean group revealed differences in concentration of more than 50 compounds. A panel of four VOCs can identify the presence of overweight/obesity with excellent accuracy. Further analysis revealed that breath isoprene, 1-decene, 1-octene, ammonia and hydrogen sulfide were significantly higher in the obese group compared with the lean group (P value < 0.01 for all). CONCLUSION: Obese children have a unique pattern of exhaled VOCs. Changes in VOCs observed in this study may help to gain insight into pathophysiological processes and pathways leading to the development of childhood obesity" |
| Keywords: | Adolescent Biomarkers/metabolism Breath Tests/*methods Child Cholesterol/biosynthesis Exhalation Feasibility Studies Humans Liver/*physiopathology Mass Spectrometry Oxidative Stress Pediatric Obesity/*metabolism/physiopathology Predictive Value of Tests T; |
| Notes: | "MedlineAlkhouri, N Eng, K Cikach, F Patel, N Yan, C Brindle, A Rome, E Hanouneh, I Grove, D Lopez, R Hazen, S L Dweik, Raed A eng P01 HL107147/HL/NHLBI NIH HHS/ RR026231/RR/NCRR NIH HHS/ P01 HL081064/HL/NHLBI NIH HHS/ HL081064/HL/NHLBI NIH HHS/ U10 HL109250/HL/NHLBI NIH HHS/ HL107147/HL/NHLBI NIH HHS/ HL103453/HL/NHLBI NIH HHS/ R21 RR026231/RR/NCRR NIH HHS/ HL109250/HL/NHLBI NIH HHS/ M01 RR018390/RR/NCRR NIH HHS/ P01 HL103453/HL/NHLBI NIH HHS/ Comparative Study Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't England 2014/03/29 Pediatr Obes. 2015 Feb; 10(1):23-9. doi: 10.1111/j.2047-6310.2014.221.x. Epub 2014 Mar 27" |
