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Environ Pollut

Title:		Is residential ambient air limonene associated with asthma? Findings from the Canadian Health Measures Survey
Author(s):		Dales RE; Cakmak S;
Address:		"Population Studies Division, Health Canada, Ottawa Hospital Research Institute and University Or Ottawa, Floor 1, Room A-128, Finance Building, 101 Tunney's Pasture Driveway, Ottawa, ON, K1A 0K9, Canada. Population Studies Division, Health Canada, Floor 1, Room A-152, Finance Building, 101 Tunney's Pasture Driveway, Ottawa, ON, K1A 0K9, Canada. Electronic address: sabit.cakmak@canada.ca"
Journal Title:		Environ Pollut
Year:		2019
Volume:		20181029
Issue:
Page Number:		966 - 970
DOI:		10.1016/j.envpol.2018.10.072
ISSN/ISBN:		1873-6424 (Electronic) 0269-7491 (Linking)
Abstract:		"Asthma is a common chronic disease. Exposure to limonene is commonplace because it may be used in the manufacture of personal care products and household cleaners. We investigated the influence of limonene on asthma in a population-based sample of approximately 3000 Canadians. During the Canada Health Measures Survey, carried out between 2012 and 2013, participants were asked if they wheezed or had a diagnosis of asthma, and underwent spirometry and measurement of the fraction of exhaled nitric oxide (FeNO). These variables were tested for an association with limonene concentrations measured in their household air samples, using linear regression analysis A 100% increase in air limonene concentration was associated with an approximate 17% adjusted relative increase wheezing with an odds ratio of 1.17 (95%CI 1.16, 1.18). The percent change in FeNO for a 100% increase in limonene was twice as large for children, 2.89% (95% CI 1.88, 4.43) compared to adults, 1.44% (95%CI 1.16, 1.79). Among boys, the odds ratio was 1.50 (95%CI 1.48, 1.52) between a 100% increase in limonene and a diagnosis of asthma. This study provides evidence that household exposure to limonene may increase the prevalence of asthma in the general population"
Keywords:		"Adult Air Pollutants/*analysis Air Pollution, Indoor/*analysis Asthma/*epidemiology Breath Tests Canada Child Environmental Monitoring/*methods Exhalation Female Health Surveys Humans Limonene/*analysis Male Nitric Oxide/analysis Prevalence Spirometry Ast;"
Notes:		"MedlineDales, Robert E Cakmak, Sabit eng England 2018/11/25 Environ Pollut. 2019 Jan; 244:966-970. doi: 10.1016/j.envpol.2018.10.072. Epub 2018 Oct 29"