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Elife

Title:		A host beetle pheromone regulates development and behavior in the nematode Pristionchus pacificus
Author(s):		Cinkornpumin JK; Wisidagama DR; Rapoport V; Go JL; Dieterich C; Wang X; Sommer RJ; Hong RL;
Address:		"Department of Biology, California State University, Northridge, Northridge, United States. Department of Bioinformatics, Max Planck Institute for Biology of Ageing, Cologne, Germany. Department for Evolutionary Biology, Max Planck Institute for Developmental Biology, Tuebingen, Germany"
Journal Title:		Elife
Year:		2014
Volume:		20141015
Issue:
Page Number:		-
DOI:		10.7554/eLife.03229
ISSN/ISBN:		2050-084X (Electronic) 2050-084X (Print) 2050-084X (Linking)
Abstract:		"Nematodes and insects are the two most speciose animal phyla and nematode-insect associations encompass widespread biological interactions. To dissect the chemical signals and the genes mediating this association, we investigated the effect of an oriental beetle sex pheromone on the development and behavior of the nematode Pristionchus pacificus. We found that while the beetle pheromone is attractive to P. pacificus adults, the pheromone arrests embryo development, paralyzes J2 larva, and inhibits exit of dauer larvae. To uncover the mechanism that regulates insect pheromone sensitivity, a newly identified mutant, Ppa-obi-1, is used to reveal the molecular links between altered attraction towards the beetle pheromone, as well as hypersensitivity to its paralyzing effects. Ppa-obi-1 encodes lipid-binding domains and reaches its highest expression in various cell types, including the amphid neuron sheath and excretory cells. Our data suggest that the beetle host pheromone may be a species-specific volatile synomone that co-evolved with necromeny"
Keywords:		"Animals Behavior, Animal/*drug effects Cloning, Molecular Coleoptera/*parasitology Embryo, Nonmammalian/drug effects Genes, Helminth Host-Parasite Interactions/*drug effects Ketones/pharmacology Larva/drug effects Models, Biological Mutation/genetics Nema;"
Notes:		"MedlineCinkornpumin, Jessica K Wisidagama, Dona R Rapoport, Veronika Go, James L Dieterich, Christoph Wang, Xiaoyue Sommer, Ralf J Hong, Ray L eng SC2 GM089602/GM/NIGMS NIH HHS/ SC3 GM105579/GM/NIGMS NIH HHS/ 1SC3GM105579/GM/NIGMS NIH HHS/ SC2GM089602/GM/NIGMS NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't England 2014/10/16 Elife. 2014 Oct 15; 3:e03229. doi: 10.7554/eLife.03229"