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Cell

Title:		Olfactory inputs to hypothalamic neurons controlling reproduction and fertility
Author(s):		Yoon H; Enquist LW; Dulac C;
Address:		"Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA"
Journal Title:		Cell
Year:		2005
Volume:		123
Issue:		4
Page Number:		669 - 682
DOI:		10.1016/j.cell.2005.08.039
ISSN/ISBN:		0092-8674 (Print) 0092-8674 (Linking)
Abstract:		"In order to gain insight into sensory processing modulating reproductive behavioral and endocrine changes, we have aimed at identifying afferent pathways to neurons synthesizing luteinizing hormone-releasing hormone (LHRH, also known as gonadotropin-releasing hormone [GnRH]), a key neurohormone of reproduction. Injection of conditional pseudorabies virus into the brain of an LHRH::CRE mouse line led to the identification of neuronal networks connected to LHRH neurons. Remarkably, and in contrast to established notions on the nature of LHRH neuronal inputs, our data identify major olfactory projection pathways originating from a discrete population of olfactory sensory neurons but fail to document any synaptic connectivity with the vomeronasal system. Accordingly, chemosensory modulation of LHRH neuronal activity and mating behavior are dramatically impaired in absence of olfactory function, while they appear unaffected in mouse mutants lacking vomeronasal signaling. Further visualization of afferents to LHRH neurons across the brain offers a unique opportunity to uncover complex polysynaptic circuits modulating reproduction and fertility"
Keywords:		"Animals Brain/cytology/physiology/virology Cyclic Nucleotide-Gated Cation Channels Female Fertility/*physiology Gonadotropin-Releasing Hormone/genetics/metabolism/physiology Green Fluorescent Proteins/genetics/metabolism Herpesvirus 1, Suid/genetics Hypot;"
Notes:		"MedlineYoon, Hayan Enquist, L W Dulac, Catherine eng 2R01-NS33506/NS/NINDS NIH HHS/ R01 DC003903/DC/NIDCD NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't 2005/11/18 Cell. 2005 Nov 18; 123(4):669-82. doi: 10.1016/j.cell.2005.08.039"