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Org Lett

Title:		Organocatalytic Enantioselective Amination of 2-Substituted Indolin-3-ones: A Strategy for the Synthesis of Chiral alpha-Hydrazino Esters
Author(s):		Yarlagadda S; Ramesh B; Ravikumar Reddy C; Srinivas L; Sridhar B; Subba Reddy BV;
Address:		"Centre for Semiochemicals and double daggerLaboratory of X-ray Crystallography, CSIR-Indian Institute of Chemical Technology , Hyderabad, 500 007, India"
Journal Title:		Org Lett
Year:		2017
Volume:		20161223
Issue:		1
Page Number:		170 - 173
DOI:		10.1021/acs.orglett.6b03473
ISSN/ISBN:		1523-7052 (Electronic) 1523-7052 (Linking)
Abstract:		An efficient enantioselective alpha-amination of 2-substituted 3-indolinones has been achieved for the first time using hydroquinidine as a chiral catalyst through an aza-Michael reaction. The desired alpha-hydrazino esters are obtained in excellent yields with high enantiomeric excess leading to a quaternary stereocenter with a broad substrate scope
Keywords:
Notes:		"PubMed-not-MEDLINEYarlagadda, Suresh Ramesh, B Ravikumar Reddy, C Srinivas, L Sridhar, B Subba Reddy, B V eng Research Support, Non-U.S. Gov't 2016/12/24 Org Lett. 2017 Jan 6; 19(1):170-173. doi: 10.1021/acs.orglett.6b03473. Epub 2016 Dec 23"