| Title: | Transgenerational Bisphenol A Causes Deficits in Social Recognition and Alters Postsynaptic Density Genes in Mice |
| Author(s): | Wolstenholme JT; Drobna Z; Henriksen AD; Goldsby JA; Stevenson R; Irvin JW; Flaws JA; Rissman EF; |
| Address: | "Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virginia. Department of Pharmacology & Toxicology, Virginia Commonwealth University, Richmond, Virginia. Center for Human Health and the Environment and Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina. Department of Integrated Science and Technology, James Madison University, Harrisonburg, Virginia. Department of Comparative Biosciences, University of Illinois, Urbana, Illinois" |
| ISSN/ISBN: | 1945-7170 (Electronic) 0013-7227 (Print) 0013-7227 (Linking) |
| Abstract: | "Bisphenol A (BPA) is a ubiquitous endocrine-disrupting chemical. Developmental exposure produces changes in behavior and gene expression in the brain. Here, we examined social recognition behaviors in mice from the third familial generation (F3) after exposure to gestational BPA. Second-generation mice were bred in one of four mating combinations to reveal whether characteristics in F3 were acquired via maternal or paternal exposures. After repeated habituation to the same mouse, offspring of dams from the BPA lineage failed to display increased investigation of a novel mouse. Genes involved in excitatory postsynaptic densities (PSDs) were examined in F3 brains using quantitative PCR. Differential expression of genes important for function and stability of PSDs were assessed at three developmental ages. Several related PSD genes-SH3 and multiple ankyrin repeat domains 1 (Shank1), Homer scaffolding protein 1c (Homer1c), DLG associated protein 1 (Gkap), and discs large MAGUK scaffold protein 4 (PSD95)-were differentially expressed in control- vs BPA-lineage brains. Using a second strain of F3 inbred mice exposed to BPA, we noted the same differences in Shank1 and PSD95 expression in C57BL/6J mice. In sum, transgenerational BPA exposure disrupted social interactions in mice and dysregulated normal expression of PSD genes during neural development. The fact that the same genetic effects were found in two different mouse strains and in several brain regions increased potential for translation. The genetic and functional relationship between PSD and abnormal neurobehavioral disorders is well established, and our data suggest that BPA may contribute in a transgenerational manner to neurodevelopmental diseases" |
| Keywords: | "Animals Benzhydryl Compounds/*toxicity Brain/drug effects/metabolism Female Fetus/*drug effects Male Mice Mice, Inbred C57BL Nerve Tissue Proteins/physiology Phenols/*toxicity Post-Synaptic Density/*drug effects *Social Behavior;" |
| Notes: | "MedlineWolstenholme, Jennifer T Drobna, Zuzana Henriksen, Anne D Goldsby, Jessica A Stevenson, Rachel Irvin, Joshua W Flaws, Jodi A Rissman, Emilie F eng P01 ES022848/ES/NIEHS NIH HHS/ R01 ES022759/ES/NIEHS NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't 2019/06/13 Endocrinology. 2019 Aug 1; 160(8):1854-1867. doi: 10.1210/en.2019-00196" |
