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Cell Tissue Res

Title:		"Peripheral projections of nervus terminalis LHRH-containing neurons in the tiger salamander, Ambystoma tigrinum"
Author(s):		Wirsig-Wiechmann CR;
Address:		"Department of Neurobiology and Anatomy, Bowman Gray School of Medicine, Winston-Salem, NC 27157-1010"
Journal Title:		Cell Tissue Res
Year:		1993
Volume:		273
Issue:		1
Page Number:		31 - 40
DOI:		10.1007/BF00304609
ISSN/ISBN:		0302-766X (Print) 0302-766X (Linking)
Abstract:		"The peripheral projections of the nervus terminalis (NT) have been difficult to examine due to the weak immunoreactivity of the processes to various antibodies. We performed two experimental manipulations in the tiger salamander in an attempt to increase the luteinizing hormone-releasing hormone-immunoreactive (LHRH-ir) labelling in the peripheral processes of the NT:1) the NT was sectioned centrally, or 2) a 100 mg melatonin pellet was embedded subcutaneously for 3 days prior to sacrifice. Following these manipulations, animals were sacrificed and tissue was processed with standard immunocytochemical techniques for the analysis of the distribution of LHRH-ir processes. In the nasal cavity, LHRH-ir fibers were observed projecting 1) into the rostral olfactory epithelium, 2) to Bowman's glands in the lamina propria of the rostromedial olfactory mucosa and ventrolateral mucosa between the main nasal cavity and Jacobson's organ, 3) into the naris constrictor muscle, and 4) along the palatine nerves and ganglia. These lesion and hormone manipulations have enabled the detection of peripheral projections of the NT not observed previously with immunocytochemical procedures alone. The wide distribution of LHRH-ir NT processes in the nasal cavity and cranium suggests that this nerve may influence many different cranial structures during appropriate pheromonal or neuroendocrine events"
Keywords:		Ambystoma/anatomy & histology/*metabolism Animals Chemoreceptor Cells/metabolism Cranial Nerves/anatomy & histology/drug effects/*metabolism Exocrine Glands/innervation Gonadotropin-Releasing Hormone/*metabolism Immunohistochemistry Melatonin/pharmacology;
Notes:		"MedlineWirsig-Wiechmann, C R eng NS27856/NS/NINDS NIH HHS/ Research Support, U.S. Gov't, P.H.S. Germany 1993/07/01 Cell Tissue Res. 1993 Jul; 273(1):31-40. doi: 10.1007/BF00304609"