| Title: | Regional differences of pheromone production in the sebaceous glands of castrated goats treated with testosterone |
| Author(s): | Wakabayashi Y; Iwata E; Kikusui T; Takeuch Y; Mori Y; |
| Address: | "Laboratory of Veterinary Ethology, The University of Tokyo, Japan" |
| ISSN/ISBN: | 0916-7250 (Print) 0916-7250 (Linking) |
| Abstract: | "The primer pheromone is responsible for the 'male effects' in goats and produced in the sebaceous glands testosterone-dependently. In the present study, the responses of sebaceous glands obtained from the head and rump regions of castrated goats were examined by our bioassay system after testosterone treatment to demonstrate the presence of regional differences in the pheromone production in male goats. The testosterone treatment resulted in the marked development of sebaceous glands and the induction of pheromone bioactivity in the head region of the goats. On the contrary, this treatment brought neither development of the sebaceous glands nor induction of pheromone bioactivity in the rump region. The treatment increased immunoreactivities to androgen receptors (AR) and 5alpha-reductase in the sebaceous glands of both regions, although the activities were more apparent in the head region than the rump region. These findings suggest that the primer pheromone of male goats is produced specifically in the sebaceous glands of the head region due partly to regional differences in the expression of AR and 5alpha-reductase mediating testosterone bioactivities" |
| Keywords: | "3-Oxo-5-alpha-Steroid 4-Dehydrogenase/biosynthesis Animals Goats/*metabolism Head Immunohistochemistry/veterinary Male Orchiectomy/veterinary Pheromones/*biosynthesis Receptors, Androgen/biosynthesis/drug effects Sebaceous Glands/drug effects/*metabolism/;" |
| Notes: | "MedlineWakabayashi, Y Iwata, E Kikusui, T Takeuch, Y Mori, Y eng Research Support, Non-U.S. Gov't Japan 2000/11/10 J Vet Med Sci. 2000 Oct; 62(10):1067-72. doi: 10.1292/jvms.62.1067" |
