| Title: | RNA editing by ADARs is important for normal behavior in Caenorhabditis elegans |
| Author(s): | Tonkin LA; Saccomanno L; Morse DP; Brodigan T; Krause M; Bass BL; |
| Address: | "Department of Biochemistry and Howard Hughes Medical Institute, University of Utah, 20 North 1900 East, Salt Lake City, UT 84132, USA" |
| ISSN/ISBN: | 0261-4189 (Print) 1460-2075 (Electronic) 0261-4189 (Linking) |
| Abstract: | "Here we take advantage of the well-characterized and simple nervous system of Caenorhabditis elegans to further our understanding of the functions of RNA editing. We describe the two C.elegans ADAR genes, adr-1 and adr-2, and characterize strains containing homozygous deletions in each, or both, of these genes. We find that adr-1 is expressed in most, if not all, cells of the C.elegans nervous system and also in the developing vulva. Using chemotaxis assays, we show that both ADARs are important for normal behavior. Biochemical, molecular and phenotypic analyses indicate that ADR-1 and ADR-2 have distinct roles in C.elegans, but sometimes act together" |
| Keywords: | "Adenosine Deaminase/*genetics/*physiology Animals *Behavior, Animal Caenorhabditis elegans/*genetics/physiology Caenorhabditis elegans Proteins/*genetics/*physiology Catalysis Catalytic Domain Chemotaxis/*genetics Diptera/metabolism Female Male Mammals/me;" |
| Notes: | "MedlineTonkin, Leath A Saccomanno, Lisa Morse, Daniel P Brodigan, Thomas Krause, Michael Bass, Brenda L eng R01 GM044073/GM/NIGMS NIH HHS/ R01 GM044073-11/GM/NIGMS NIH HHS/ GM 44073/GM/NIGMS NIH HHS/ CA 42014/CA/NCI NIH HHS/ Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. England 2002/11/12 EMBO J. 2002 Nov 15; 21(22):6025-35. doi: 10.1093/emboj/cdf607" |
