| Title: | Sequence variations at the human leukocyte antigen-linked olfactory receptor cluster do not influence female preferences for male odors |
| Author(s): | Thompson EE; Haller G; Pinto JM; Sun Y; Zelano B; Jacob S; McClintock MK; Nicolae DL; Ober C; |
| Address: | "Department of Human Genetics, The University of Chicago, Chicago, Illinois, USA. eethomps@uchicago.edu" |
| DOI: | 10.1016/j.humimm.2009.10.004 |
| ISSN/ISBN: | 1879-1166 (Electronic) 0198-8859 (Print) 0198-8859 (Linking) |
| Abstract: | "We previously reported that paternally inherited human leukocyte antigen (HLA) alleles are a template for women's preferences for male odors (p = 0.0007). However, it has been suggested that sequence variation in a nearby olfactory receptor (OR) cluster on chromosome 6p influences smell preference. To determine whether the HLA-linked OR genes contribute to previously observed HLA-mediated behaviors, we use the odor preference data from our earlier study in combination with a new resequencing study of four functional, HLA-linked OR genes in the same subjects. Our results indicate that OR alleles in the genes surveyed are not in linkage disequilibrium with HLA variation and do not explain the previous findings of HLA-associated odor preference" |
| Keywords: | "Adolescent Adult Base Sequence Chromosomes, Human, Pair 6 Female Genetic Linkage HLA Antigens/*genetics/immunology Humans Male Middle Aged *Multigene Family *Olfactory Perception Pheromones, Human/metabolism *Polymorphism, Single Nucleotide Receptors, Odo;" |
| Notes: | "MedlineThompson, Emma E Haller, Gabe Pinto, Jayant M Sun, Ying Zelano, Bethanne Jacob, Suma McClintock, Martha K Nicolae, Dan L Ober, Carole eng K23 AG036762/AG/NIA NIH HHS/ R01 HD021244/HD/NICHD NIH HHS/ T32 HL007605/HL/NHLBI NIH HHS/ HD21244/HD/NICHD NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't 2009/10/17 Hum Immunol. 2010 Jan; 71(1):100-3. doi: 10.1016/j.humimm.2009.10.004" |
