« Previous Abstract"Short-term effect of strontium- and zinc-containing toothpastes and mouthrinses on volatile sulphur compounds in morning breath: a randomized, double-blind, cross-over clinical study"    Next AbstractTowards DNA-Based Methods Analysis for Honey: An Update »

J Endocrinol

Title:		Progestagen effects on elicitation of aggressive behaviour in male mice
Author(s):		Soares MJ; Kalberer WD; Erpino MJ;
Address:
Journal Title:		J Endocrinol
Year:		1977
Volume:		73
Issue:		3
Page Number:		507 - 510
DOI:		10.1677/joe.0.0730507
ISSN/ISBN:		0022-0795 (Print) 0022-0795 (Linking)
Abstract:		"Effects of progesterone on production of androgen-dependent aggression-eliciting pheromones were investigated. Two groups of anosmic (non-fighting) castrated mice treated with testosterone or with testosterone and progesterone, respectively, were attacked to the same degree by intact, isolated (fighting) mice while control mice (castrated only) were attacked less. The findings support the ideas that progesterone may inhibit androgen-induced aggression via a neural and not via a somatic mechanism. The effects of progestagen on elicitation of aggressive behavior in male mice were tested. 48 mice were divided as follows: 1) 16 mice used as pheromone testers; 2) 24 mice bilaterally gonadectomized and subcutaneously implanted with either 20 mg testosterone (T), T + progesterone (P), or control beads; and 3) 8 mice sham-castrated and implanted with control beads. 4 days after the beginning of replacement therapy the treated mice were placed on an 18-hour food deprivation schedule in preparation for olfaction tests. A mouse was considered nonaggressive if response was absent (locating a food pellet) within 5 minutes. Zinc sulphate was administered intranasally to produce a peripheral olfactory dysfunction and produce anosmia. P failed to interfere with the actions of T in the production of aggression-eliciting pheromones and in the maintenance of the preputial and seminal vesicle-coagulating glands. Mice which were only castrated were attacked less than either T-treated or T + P-treated mice. eng"
Keywords:		"Aggression/*drug effects Animals Castration Humans Male Olfaction Disorders/metabolism Pheromones/metabolism Progesterone/*pharmacology Rats Testosterone/antagonists & inhibitors/pharmacology Androgens *Animals, Laboratory Biology *Castration Clinical Res;"
Notes:		"MedlineSoares, M J Kalberer, W D Erpino, M J eng England 1977/06/01 J Endocrinol. 1977 Jun; 73(3):507-10. doi: 10.1677/joe.0.0730507"