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Am J Otolaryngol

Title:		Sensorineural hearing loss and volatile organic compound metabolites in urine
Author(s):		Pudrith C; Dudley WN;
Address:		"Department of Allied Health and Communicative Disorders, Northern Illinois University, IL, United States of America. Electronic address: cpudrith@niu.edu. Department of Public Health Education, University of North Carolina at Greensboro, NC, United States of America. Electronic address: wndudley@uncg.edu"
Journal Title:		Am J Otolaryngol
Year:		2019
Volume:		20190304
Issue:		3
Page Number:		409 - 412
DOI:		10.1016/j.amjoto.2019.03.001
ISSN/ISBN:		1532-818X (Electronic) 0196-0709 (Linking)
Abstract:		"PURPOSE: Oxidative stress in the auditory system contributes to acquired sensorineural hearing loss. Systemic oxidative stress, which may predict auditory oxidative stress, can be assessed by measuring volatile organic compound metabolite concentrations in urine. The purpose of this retrospective study was to determine if hearing decreased in those with higher concentrations of urinary volatile organic compound metabolites. MATERIALS AND METHODS: Audiometric, demographic, and metabolite concentration data were downloaded from the 2011-2012 cycle of the U.S. National Health and Nutritional Examination Survey. Participants were first grouped by reported noise exposure. For each metabolite, an analysis of covariance was used to look for differences in age-adjusted hearing loss among urinary volatile organic compound metabolite concentration groups. Participants were grouped into quartiles based on concentration for each metabolite separately because many individuals were at the lower limit of concentration detection for several metabolites, leading to a non-normal distribution. RESULTS: Age-adjusted high-frequency pure-tone thresholds were significantly (FDR?ª+
Keywords:		"Acetylcysteine/*urine Acrylamide/metabolism Acrylonitrile/metabolism Adult Audiometry, Pure-Tone Auditory Threshold Biomarkers/urine Butadienes/metabolism Dimethylformamide/metabolism Female Hearing Loss, Sensorineural/*diagnosis/*etiology Humans Male Mid;"
Notes:		"MedlinePudrith, Charles Dudley, William N eng 2019/03/16 Am J Otolaryngol. 2019 May-Jun; 40(3):409-412. doi: 10.1016/j.amjoto.2019.03.001. Epub 2019 Mar 4"