| Title: | Ecological risk assessment of alpha-cypermethrin-treated food ingestion and reproductive toxicity in reptiles |
| Author(s): | Chen L; Wang D; Zhang W; Wang F; Zhang L; Wang Z; Li Y; Zhou Z; Diao J; |
| Address: | "Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Applied Chemistry, China Agricultural University, Yuanmingyuan West Road 2, Beijing 100193, China. College of Plant Protection, China Agricultural University, Yuanmingyuan West Road 2, Beijing 100193, China. Department of Applied Chemistry, China Agricultural University, Yuanmingyuan West Road 2, Beijing 100193, China. Electronic address: lingyinzi1201@gmail.com" |
| DOI: | 10.1016/j.ecoenv.2019.01.012 |
| ISSN/ISBN: | 1090-2414 (Electronic) 0147-6513 (Linking) |
| Abstract: | "Pesticides are proposed as one of the many causes for the global decline in reptile population. To understand the potential impact of alpha-cypermethrin (ACP) in reptiles, in the current study, we used a tri-trophic food web (plants - herbivores - natural enemies of predators) to examine the reproductive toxicity and biomarker changes. Based on the Maximum Residue Limit (MRL) of ACP in several agricultural products, we designed three concentrations 0, 2 (MRL), and 20?ª+mg/kg (wet weight) as three treatment groups for this research. Male and female lizards were fed ACP contaminated or uncontaminated diets for eight weeks during the breeding phase. The number of deaths was different among the three groups, and a dose-dependent trend was found. Decreases in food consumption of 26.6% and 28.1% were observed in the low- and high-dose group, respectively. Dietary exposure significantly induced a dose-dependent decrease in body mass index in lizards. Significant variations in glutathione-S-transferaseb activities, catalase activities, and malondialdehyde levels in gonads, suggest that lizards were under oxidative stress. In addition, ACP exposure altered sexual hormone levels in males, reduced reproductive output of females, and induced histopathological changes in testes. These negative effects highlight that ACP dietary exposure is a potential threat to lizards' reproduction" |
| Keywords: | "Animals Biomarkers/blood Catalase/blood Diet/*veterinary Dose-Response Relationship, Drug Ecology Estradiol/blood Female *Lizards Male Malondialdehyde/blood Oxidative Stress/drug effects Pesticides/*toxicity Pyrethrins/*toxicity Reproduction/*drug effects;" |
| Notes: | "MedlineChen, Li Wang, Dezhen Zhang, Wenjun Wang, Fang Zhang, Luyao Wang, Zikang Li, Yao Zhou, Zhiqiang Diao, Jinling eng Netherlands 2019/01/19 Ecotoxicol Environ Saf. 2019 Apr 30; 171:657-664. doi: 10.1016/j.ecoenv.2019.01.012. Epub 2019 Jan 15" |
