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Cell Rep

Title:		An olfactory subsystem that mediates high-sensitivity detection of volatile amines
Author(s):		Pacifico R; Dewan A; Cawley D; Guo C; Bozza T;
Address:		"Department of Neurobiology, Northwestern University, Evanston, IL 60208, USA"
Journal Title:		Cell Rep
Year:		2012
Volume:		20120628
Issue:		1
Page Number:		76 - 88
DOI:		10.1016/j.celrep.2012.06.006
ISSN/ISBN:		2211-1247 (Electronic)
Abstract:		"Olfactory stimuli are detected by over 1,000 odorant receptors in mice, with each receptor being mapped to specific glomeruli in the olfactory bulb. The trace amine-associated receptors (TAARs) are a small family of evolutionarily conserved olfactory receptors whose contribution to olfaction remains enigmatic. Here, we show that a majority of the TAARs are mapped to a discrete subset of glomeruli in the dorsal olfactory bulb of the mouse. This TAAR projection is distinct from the previously described class I and class II domains, and is formed by a sensory neuron population that is restricted to express TAAR genes prior to choice. We also show that the dorsal TAAR glomeruli are selectively activated by amines at low concentrations. Our data uncover a hard-wired, parallel input stream in the main olfactory pathway that is specialized for the detection of volatile amines"
Keywords:		"Amines/*metabolism Animals Female Gene Targeting Mice Mice, Inbred C57BL Mice, Transgenic Models, Biological Multigene Family/physiology Olfactory Pathways/metabolism/*physiology Olfactory Perception/genetics/*physiology Olfactory Receptor Neurons/metabol;"
Notes:		"MedlinePacifico, Rodrigo Dewan, Adam Cawley, Dillon Guo, Caiying Bozza, Thomas eng F32 DC012004/DC/NIDCD NIH HHS/ R01 DC009640/DC/NIDCD NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't 2012/07/31 Cell Rep. 2012 Jul 26; 2(1):76-88. doi: 10.1016/j.celrep.2012.06.006. Epub 2012 Jun 28"