| Title: | Phospholipase D function in Saccharomyces cerevisiae |
| Author(s): | Mendonsa R; Engebrecht J; |
| Address: | "Department of Molecular and Cellular Biology, University of California, Davis, Davis, CA 95616, USA" |
| DOI: | 10.1016/j.bbalip.2009.01.013 |
| ISSN/ISBN: | 0006-3002 (Print) 0006-3002 (Linking) |
| Abstract: | "Phosphatidylinositol 4,5-bisphosphate-regulated phosphatidylcholine-specific phospholipase D is conserved from yeast to man. The essential role of this enzyme in yeast is to mediate the fusion of Golgi and endosome-derived vesicles to generate the prospore membrane during the developmental program of sporulation, through the production of the fusogenic lipid phosphatidic acid. In addition to recruiting proteins required for fusion, phosphatidic acid is believed to lower the energy barrier to stimulate membrane curvature. During mitotic growth, phospholipase D activity is dispensable unless the major phosphatidylinositol/phosphatidylcholine transfer protein is absent; it also appears to play a nonessential role in the mating signal transduction pathway. The regulation of phospholipase D activity during both sporulation and mitotic growth is still not fully understood and awaits further characterization" |
| Keywords: | Cell Membrane/enzymology Lipids/biosynthesis Pheromones/metabolism Phospholipase D/chemistry/*metabolism Reproduction Saccharomyces cerevisiae/cytology/*enzymology/metabolism; |
| Notes: | "MedlineMendonsa, Rima Engebrecht, JoAnne eng GM66124/GM/NIGMS NIH HHS/ Research Support, N.I.H., Extramural Review Netherlands 2009/05/07 Biochim Biophys Acta. 2009 Sep; 1791(9):970-4. doi: 10.1016/j.bbalip.2009.01.013. Epub 2009 Jan 30" |
