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Science

Title:		Yeast mating pheromone activates mammalian gonadotrophs: evolutionary conservation of a reproductive hormone?
Author(s):		Loumaye E; Thorner J; Catt KJ;
Address:
Journal Title:		Science
Year:		1982
Volume:		218
Issue:		4579
Page Number:		1323 - 1325
DOI:		10.1126/science.6293058
ISSN/ISBN:		0036-8075 (Print) 0036-8075 (Linking)
Abstract:		"alpha-Factor, a tridecapeptide mating pheromone of yeast (Saccharomyces cerevisiae), has extensive sequence homology with the hypothalamic decapeptide gonadotropin-releasing hormone (GnRH). Both synthetic and natural preparations of alpha-mating factor were found to bind specifically to rat pituitary GnRH receptors and to stimulate the release of luteinizing hormone from cultured gonadotrophs. The ability of the yeast pheromone to reproduce the biological actions of GnRH in the mammalian pituitary gland indicates that the structural and functional properties of GnRH-related peptides may have been highly conserved during evolution"
Keywords:		"Animals Dose-Response Relationship, Drug Luteinizing Hormone/metabolism Mating Factor Peptides/*pharmacology Pituitary Gland/drug effects/metabolism Rats Receptors, Cell Surface/*drug effects Receptors, LHRH Saccharomyces cerevisiae/*analysis;"
Notes:		"MedlineLoumaye, E Thorner, J Catt, K J eng 1982/12/24 Science. 1982 Dec 24; 218(4579):1323-5. doi: 10.1126/science.6293058"