« Previous AbstractThermodynamic assessment of (semi-)volatile hydrophobic organic chemicals in WWTP sludge - combining solid phase microextraction with non-target GC/MS    Next AbstractThe role of disease in bee foraging ecology »

J Breath Res

Title:		The role of mathematical modeling in VOC analysis using isoprene as a prototypic example
Author(s):		Koc H; King J; Teschl G; Unterkofler K; Teschl S; Mochalski P; Hinterhuber H; Amann A;
Address:		"Vorarlberg University of Applied Sciences, Hochschulstr. 1, A-6850 Dornbirn, Austria"
Journal Title:		J Breath Res
Year:		2011
Volume:		20110607
Issue:		3
Page Number:		37102 -
DOI:		10.1088/1752-7155/5/3/037102
ISSN/ISBN:		1752-7163 (Electronic) 1752-7155 (Linking)
Abstract:		"Isoprene is one of the most abundant endogenous volatile organic compounds (VOCs) contained in human breath and is considered to be a potentially useful biomarker for diagnostic and monitoring purposes. However, neither the exact biochemical origin of isoprene nor its physiological role is understood in sufficient depth, thus hindering the validation of breath isoprene tests in clinical routine. Exhaled isoprene concentrations are reported to change under different clinical and physiological conditions, especially in response to enhanced cardiovascular and respiratory activity. Investigating isoprene exhalation kinetics under dynamical exercise helps to gather the relevant experimental information for understanding the gas exchange phenomena associated with this important VOC. The first model for isoprene in exhaled breath has been developed by our research group. In this paper, we aim at giving a concise overview of this model and describe its role in providing supportive evidence for a peripheral (extrahepatic) source of isoprene. In this sense, the results presented here may enable a new perspective on the biochemical processes governing isoprene formation in the human body"
Keywords:		"Breath Tests/*methods Butadienes/*pharmacokinetics Exhalation Hemiterpenes/*pharmacokinetics Humans *Models, Theoretical Pentanes/*pharmacokinetics Pulmonary Gas Exchange/*physiology;"
Notes:		"MedlineKoc, H King, J Teschl, G Unterkofler, K Teschl, S Mochalski, P Hinterhuber, H Amann, A eng Research Support, Non-U.S. Gov't Review England 2011/06/10 J Breath Res. 2011 Sep; 5(3):037102. doi: 10.1088/1752-7155/5/3/037102. Epub 2011 Jun 7"