| Title: | "Social behaviours by Bacillus subtilis: quorum sensing, kin discrimination and beyond" |
| Author(s): | Kalamara M; Spacapan M; Mandic-Mulec I; Stanley-Wall NR; |
| Address: | "Division of Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee, DD15EH, UK. Department of Food Science and Technology, Biotechnical Faculty, University of Ljubljana, Ljubljana, 1000, Slovenia" |
| ISSN/ISBN: | 1365-2958 (Electronic) 0950-382X (Print) 0950-382X (Linking) |
| Abstract: | "Here, we review the multiple mechanisms that the Gram-positive bacterium Bacillus subtilis uses to allow it to communicate between cells and establish community structures. The modes of action that are used are highly varied and include routes that sense pheromone levels during quorum sensing and control gene regulation, the intimate coupling of cells via nanotubes to share cytoplasmic contents, and long-range electrical signalling to couple metabolic processes both within and between biofilms. We explore the ability of B. subtilis to detect 'kin' (and 'cheater cells') by looking at the mechanisms used to potentially ensure beneficial sharing (or limit exploitation) of extracellular 'public goods'. Finally, reflecting on the array of methods that a single bacterium has at its disposal to ensure maximal benefit for its progeny, we highlight that a large future challenge will be integrating how these systems interact in mixed-species communities" |
| Keywords: | "Bacillus subtilis/classification/*genetics/*metabolism Bacterial Proteins/*genetics Biofilms/growth & development Gene Expression Regulation, Bacterial Quorum Sensing/*genetics Signal Transduction;" |
| Notes: | "MedlineKalamara, Margarita Spacapan, Mihael Mandic-Mulec, Ines Stanley-Wall, Nicola R eng [P4-0116; J4-7637; J4-9302]/Slovenian research agency/International P001335/Biotechnology and Biological Sciences Research Council/United Kingdom R012415/Biotechnology and Biological Sciences Research Council/United Kingdom 1/Biotechnology and Biological Sciences Research Council/United Kingdom P4-0116,/Biotechnology and Biological Sciences Research Council/United Kingdom J4-7637/Biotechnology and Biological Sciences Research Council/United Kingdom P4-0116/Slovenian research agency/International J4-7637/Slovenian research agency/International J4-9302/Slovenian research agency/International BB/P001335/1/Biotechnology and Biological Sciences Research Council/United Kingdom BB/R012415/1/Biotechnology and Biological Sciences Research Council/United Kingdom Research Support, Non-U.S. Gov't Review England 2018/09/16 Mol Microbiol. 2018 Dec; 110(6):863-878. doi: 10.1111/mmi.14127. Epub 2018 Nov 1" |
