| Title: | Biomphalaria glabrata immunity: Post-genome advances |
| Author(s): | Castillo MG; Humphries JE; Mourao MM; Marquez J; Gonzalez A; Montelongo CE; |
| Address: | "Department of Biology, New Mexico State University, Las Cruces, NM 88003, USA. Electronic address: mcastill@nmsu.edu. Department of Biology, Lawrence University, Appleton WI 54911, USA. Centro de Pesquisas Rene Rachou, Fundacao Oswaldo Cruz, Fiocruz Minas, Brazil. Department of Biology, New Mexico State University, Las Cruces, NM 88003, USA" |
| DOI: | 10.1016/j.dci.2019.103557 |
| ISSN/ISBN: | 1879-0089 (Electronic) 0145-305X (Print) 0145-305X (Linking) |
| Abstract: | "The freshwater snail, Biomphalaria glabrata, is an important intermediate host in the life cycle for the human parasite Schistosoma mansoni, the causative agent of schistosomiasis. Current treatment and prevention strategies have not led to a significant decrease in disease transmission. However, the genome of B. glabrata was recently sequenced to provide additional resources to further our understanding of snail biology. This review presents an overview of recently published, post-genome studies related to the topic of snail immunity. Many of these reports expand on findings originated from the genome characterization. These novel studies include a complementary gene linkage map, analysis of the genome of the B. glabrata embryonic (Bge) cell line, as well as transcriptomic and proteomic studies looking at snail-parasite interactions and innate immune memory responses towards schistosomes. Also included are biochemical investigations on snail pheromones, neuropeptides, and attractants, as well as studies investigating the frontiers of molluscan epigenetics and cell signaling were also included. Findings support the current hypotheses on snail-parasite strain compatibility, and that snail host resistance to schistosome infection is dependent not only on genetics and expression, but on the ability to form multimeric molecular complexes in a timely and tissue-specific manner. The relevance of cell immunity is reinforced, while the importance of humoral factors, especially for secondary infections, is supported. Overall, these studies reflect an improved understanding on the diversity, specificity, and complexity of molluscan immune systems" |
| Keywords: | "Animals Biomphalaria/*immunology Disease Vectors Epigenomics Genome Host-Parasite Interactions Humans Immunity, Cellular Proteomics Schistosoma mansoni/*physiology Schistosomiasis/*transmission Signal Transduction Transcriptome;" |
| Notes: | "MedlineCastillo, Maria G Humphries, Judith E Mourao, Marina M Marquez, Joshua Gonzalez, Adrian Montelongo, Cesar E eng SC2 AI133645/AI/NIAID NIH HHS/ Research Support, N.I.H., Extramural Review 2019/11/25 Dev Comp Immunol. 2020 Mar; 104:103557. doi: 10.1016/j.dci.2019.103557. Epub 2019 Nov 21" |
