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Environ Toxicol

Title:		Role of Th2 cytokines on the onset of asthma induced by meta-xylene in mice
Author(s):		Hong SG; Hwang YH; Mun SK; Kim SJ; Jang HY; Kim H; Paik MJ; Yee ST;
Address:		"Department of Pharmacy, Sunchon National University, Suncheon, Republic of Korea"
Journal Title:		Environ Toxicol
Year:		2019
Volume:		20190625
Issue:		10
Page Number:		1121 - 1128
DOI:		10.1002/tox.22814
ISSN/ISBN:		1522-7278 (Electronic) 1520-4081 (Linking)
Abstract:		"meta-Xylene (m-xylene) is one of three isomers of xylene, which is widely used as a solvent and detergent in various industries and medical technology. Exposure to volatile organic compounds, such as m-xylene, causes pulmonary inflammation and airway inflammation, thereby contributing to the onset of asthma. Exposure to m-xylene increases acute wheezing and intensity of asthma symptom. However, the mechanism of the onset of asthma by m-xylene has not been studied yet. C57BL/6 mice were sensitized and challenged by m-xylene at 100 or 300 mg/kg. The mice were then sacrificed after the last challenge. Exposure to m-xylene increased the total number of inflammatory cells and the production of interleukin (IL)-4, IL-5, IL-13, and immunoglobulin E related to the Th2 immune response. In contrast, the production of interferon-gamma related to the Th1 immune response was decreased. In addition, the airway resistance increased according to the airway hyper-responsiveness measurements. Finally, a histological analysis revealed infiltration of inflammatory cells, mucus production, and lung fibrosis. These results suggest that m-xylene is a potential risk factor for asthma and the onset of asthma is caused by TH2 cytokines"
Keywords:		Animals Asthma/*chemically induced/genetics/immunology Bronchoalveolar Lavage Fluid/immunology Cytokines/genetics/*immunology Female Humans Immunoglobulin E/immunology Interleukin-13/genetics/immunology Interleukin-4/genetics/immunology Interleukin-5/gene;
Notes:		"MedlineHong, Seong-Gyeol Hwang, Yun-Ho Mun, Seul-Ki Kim, Su-Jin Jang, Ho-Yeol Kim, Hangun Paik, Man-Jeong Yee, Sung-Tae eng 2015R1A4A1041219/National Research Foundation of Korea/ 2019/06/27 Environ Toxicol. 2019 Oct; 34(10):1121-1128. doi: 10.1002/tox.22814. Epub 2019 Jun 25"