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Arch Microbiol

Title:		Selective inhibition of transition from sexual agglutination to zygote formation by ethyl N-phenylcarbamate in Saccharomyces cerevisiae
Author(s):		Hasegawa S; Yanagishima N;
Address:
Journal Title:		Arch Microbiol
Year:		1984
Volume:		137
Issue:		3
Page Number:		188 - 193
DOI:		10.1007/BF00414541
ISSN/ISBN:		0302-8933 (Print) 0302-8933 (Linking)
Abstract:		"Effects of ethyl N-phenylcarbamate (EPC) on the mating reaction of Saccharomyces cerevisiae were studied, with special attention on the effect on the alpha pheromone action. EPC inhibited zygote formation at a concentration which promoted induction of sexual agglutinability. EPC enhanced agglutinability induction by alpha pheromone, but inhibited alpha-pheromone-induced formation of large pearshaped cells in a mating type. The enhancement of agglutinability induction was accompanied with increased production of a agglutination substance and inhibition of alpha pheromone inactivation. EPC arrested the cell cycle of a cells probably in the step controlled by CDC19, CDC35, cAMP etc., just before the step controlled by CDC28, alpha pheromone etc"
Keywords:		Agglutination Carbamates/*pharmacology Cell Cycle/drug effects Mating Factor Microtubules/drug effects/*physiology Peptides/*physiology *Phenylcarbamates Reproduction/drug effects Saccharomyces cerevisiae/cytology/drug effects/*physiology/ultrastructure *;
Notes:		"MedlineHasegawa, S Yanagishima, N eng Research Support, Non-U.S. Gov't Germany 1984/03/01 Arch Microbiol. 1984 Mar; 137(3):188-93. doi: 10.1007/BF00414541"