| Title: | Prenatal exposure to VOCs and NOx and lung function in preschoolers |
| Author(s): | Gutierrez-Delgado RI; Barraza-Villarreal A; Escamilla-Nunez MC; Hernandez-Cadena L; Cortez-Lugo M; Sly P; Romieu I; |
| Address: | "Departamento de Salud Ambiental, Instituto Nacional de Salud Publica, Cuernavaca, Morelos, Mexico. Department of Children's Health and Environment, The University of Queensland, Brisbane, Queensland, Australia. WHO Collaborating Centre for Research on Children's Environmental Health, Perth, Australia" |
| ISSN/ISBN: | 1099-0496 (Electronic) 8755-6863 (Print) 1099-0496 (Linking) |
| Abstract: | "BACKGROUND: Several studies have shown that exposure to air pollutants affects lung growth and development and can result in poor respiratory health in early life. METHODS: We included a subsample of 772 Mexican preschoolers whose mothers participated in a Prenatal Omega-3 fatty acid Supplements, GRowth, And Development birth cohort study with the aim to evaluate the impact of prenatal exposure to volatile organic compounds and nitrogen oxides on lung function measured by oscillation tests. The preschoolers were followed until 5 years of age. Anthropometric measurements and forced oscillation tests were performed at 36, 48, and 60 months of age. Information on sociodemographic and health characteristics was obtained during follow up. Prenatal exposure to volatile organic compounds and nitrogen oxides was evaluated using a land use regression models and the association between them was tested using a lineal regression and longitudinal linear mixed effect models adjusting for potential confounders. RESULTS: Overall, the mean (standard deviation) of the measurements of respiratory system resistance and respiratory system reactance at 6, 8, and 10 Hz during the follow-up period was 11.3 (2.4), 11.1 (2.4), 10.3 (2.2) and -5.2 (1.6), -4.8 (1.7), and -4.6 hPa s L(-1) (1.6), respectively. We found a significantly positive association between respiratory resistance (beta(Rrs6) = 0.011; 95%CI: 0.001, 0.023) (P < .05) and prenatal exposure to nitrogen dioxide and a marginally negatively association between respiratory reactance (beta(Xrs6) = -11.40 95%CI: -25.26, 1.17 and beta(Xrs8) = -11.91 95%CI: -26.51, 1.43) (P = .07) and prenatal exposure to xylene. CONCLUSION: Prenatal exposure to air pollutants was significantly associated with the alteration of lung function measured by oscillation tests in these preschool children" |
| Keywords: | "Air Pollutants/analysis/*toxicity Child, Preschool Cohort Studies Environmental Exposure/*adverse effects/analysis Female Humans Lung/*drug effects/physiology Male Maternal-Fetal Exchange Nitrogen Oxides/analysis/*toxicity Pregnancy *Prenatal Exposure Del;" |
| Notes: | "MedlineGutierrez-Delgado, Rosa I Barraza-Villarreal, Albino Escamilla-Nunez, Maria C Hernandez-Cadena, Leticia Cortez-Lugo, Marlene Sly, Peter Romieu, Isabelle eng R01 HD058818/HD/NICHD NIH HHS/ R01HD058818/HD/NICHD NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't 2020/06/09 Pediatr Pulmonol. 2020 Aug; 55(8):2142-2149. doi: 10.1002/ppul.24889. Epub 2020 Jun 25" |
