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Virus Res

Title:		Modelling and manipulation of aphid-mediated spread of non-persistently transmitted viruses
Author(s):		Carr JP; Tungadi T; Donnelly R; Bravo-Cazar A; Rhee SJ; Watt LG; Mutuku JM; Wamonje FO; Murphy AM; Arinaitwe W; Pate AE; Cunniffe NJ; Gilligan CA;
Address:		"Department of Plant Sciences, University of Cambridge, Cambridge CB2 3EA, UK. Electronic address: jpc1005@hermes.cam.ac.uk. Department of Plant Sciences, University of Cambridge, Cambridge CB2 3EA, UK. Department of Plant Sciences, University of Cambridge, Cambridge CB2 3EA, UK; Biosciences Eastern and Central Africa-International Livestock Research Institute (BecA-ILRI) Hub, P.O. Box 30709-00100, Nairobi, Kenya. Department of Plant Sciences, University of Cambridge, Cambridge CB2 3EA, UK; International Centre of Insect Physiology and Ecology, 30772-00100 Nairobi, Kenya"
Journal Title:		Virus Res
Year:		2020
Volume:		20191223
Issue:
Page Number:		197845 -
DOI:		10.1016/j.virusres.2019.197845
ISSN/ISBN:		1872-7492 (Electronic) 0168-1702 (Print) 0168-1702 (Linking)
Abstract:		"Aphids vector many plant viruses in a non-persistent manner i.e., virus particles bind loosely to the insect mouthparts (stylet). This means that acquisition of virus particles from infected plants, and inoculation of uninfected plants by viruliferous aphids, are rapid processes that require only brief probes of the plant's epidermal cells. Virus infection alters plant biochemistry, which causes changes in emission of volatile organic compounds and altered accumulation of nutrients and defence compounds in host tissues. These virus-induced biochemical changes can influence the migration, settling and feeding behaviours of aphids. Working mainly with cucumber mosaic virus and several potyviruses, a number of research groups have noted that in some plants, virus infection engenders resistance to aphid settling (sometimes accompanied by emission of deceptively attractive volatiles, that can lead to exploratory penetration by aphids without settling). However, in certain other hosts, virus infection renders plants more susceptible to aphid colonisation. It has been suggested that induction of resistance to aphid settling encourages transmission of non-persistently transmitted viruses, while induction of susceptibility to settling retards transmission. However, recent mathematical modelling indicates that both virus-induced effects contribute to epidemic development at different scales. We have also investigated at the molecular level the processes leading to induction, by cucumber mosaic virus, of feeding deterrence versus susceptibility to aphid infestation. Both processes involve complex interactions between specific viral proteins and host factors, resulting in manipulation or suppression of the plant's immune networks"
Keywords:		"Animals Aphids/physiology/*virology Feeding Behavior Host-Pathogen Interactions/*physiology Insect Vectors/physiology *Models, Theoretical Plant Diseases/*virology Plant Viruses/*genetics/physiology Plants/chemistry Virus Diseases/*transmission Volatile O;"
Notes:		"MedlineCarr, John P Tungadi, Trisna Donnelly, Ruairi Bravo-Cazar, Ana Rhee, Sun-Ju Watt, Lewis G Mutuku, J Musembi Wamonje, Francis O Murphy, Alex M Arinaitwe, Warren Pate, Adrienne E Cunniffe, Nik J Gilligan, Christopher A eng Research Support, Non-U.S. Gov't Review Netherlands 2019/12/25 Virus Res. 2020 Feb; 277:197845. doi: 10.1016/j.virusres.2019.197845. Epub 2019 Dec 23"