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Environ Res

Title:		"Persistent organic pollutants as predictors of increased FSH:LH ratio in naturally cycling, reproductive age women"
Author(s):		Gallo MV; Ravenscroft J; Carpenter DO; Schell LM; Akwesasne Task Force On The E;
Address:		"University at Albany, Department of Anthropology, A&S 237, 1400 Washington Ave., Albany, NY, USA; Center for the Elimination of Minority Health Disparities, University at Albany-SUNY, 1400 Washington Ave., Albany, NY, USA; Institute for Health and the Environment, University at Albany, 5 University Place, Rensselaer, NY, USA. Electronic address: mvgallo@albany.edu. University at Albany, Department of Anthropology, A&S 237, 1400 Washington Ave., Albany, NY, USA. Center for the Elimination of Minority Health Disparities, University at Albany-SUNY, 1400 Washington Ave., Albany, NY, USA; Institute for Health and the Environment, University at Albany, 5 University Place, Rensselaer, NY, USA. University at Albany, Department of Anthropology, A&S 237, 1400 Washington Ave., Albany, NY, USA; Center for the Elimination of Minority Health Disparities, University at Albany-SUNY, 1400 Washington Ave., Albany, NY, USA; Institute for Health and the Environment, University at Albany, 5 University Place, Rensselaer, NY, USA; University at Albany, Department of Epidemiology and Biostatistics, School of Public Health, One University Place, Room 131, Rensselaer, NY, USA. Akwesasne Task Force on the Environment, Akwesasne Mohawk Nation, Akwesasne, NY, USA"
Journal Title:		Environ Res
Year:		2018
Volume:		20180402
Issue:
Page Number:		556 - 564
DOI:		10.1016/j.envres.2018.03.021
ISSN/ISBN:		1096-0953 (Electronic) 0013-9351 (Print) 0013-9351 (Linking)
Abstract:		"Although several recent studies suggest endocrine disrupting compounds, such as polychlorinated biphenyls (PCBs), dichlorodiphenyldichloroethylene (p,p', DDE), and hexachlorobenzene (HCB), target different organs and systems in the body, their impact on female reproductive function in humans is not well characterized. We seek to determine the relationship between several known endocrine disrupting compounds and a marker of ovarian responsivity, the FSH:LH ratio (higher ratio indicates less ovarian responsivity). For this analysis, 169 naturally cycling women between 21 and 38 years of age completed interviews and had their blood drawn on day 3 of their menstrual cycle for analyses of toxicants, gonadal sex hormones (E(2) and P(4)), and gonadotropins (FSH and LH). PCB congeners were classified into five groups based on their environmental persistence, distribution in human tissue, and toxicological action, reflecting the structure, mechanism, and known biological activity of individual PCB congeners. For every unit (ppb) increase in the level of the estrogenic PCB group, there was a 5-fold greater risk of a FSH:LH ratio >/=?ª+2, controlling for individual differences in age, percent body fat, cycle day 3 estradiol levels, parity, alcohol use and cigarette smoking in the past year (exp[ss] = 5; p?ª+=?ª+
Keywords:		Adult Aged Dichlorodiphenyl Dichloroethylene/blood *Environmental Pollutants/blood Female Follicle Stimulating Hormone Humans *Polychlorinated Biphenyls/blood Pregnancy Young Adult Endocrine disrupting chemicals Fsh FSH:LH ratio Hcb Lh Luteinizing hormone;
Notes:		"MedlineGallo, Mia V Ravenscroft, Julia Carpenter, David O Schell, Lawrence M Akwesasne Task Force On The Environment eng P20 MD003373/MD/NIMHD NIH HHS/ S21 MD010692/MD/NIMHD NIH HHS/ Research Support, N.I.H., Extramural Netherlands 2018/04/06 Environ Res. 2018 Jul; 164:556-564. doi: 10.1016/j.envres.2018.03.021. Epub 2018 Apr 2"