| Title: | Transient receptor potential channels and mechanosensation |
| Author(s): | Eijkelkamp N; Quick K; Wood JN; |
| Address: | "Laboratory of Neuroimmunology and Developmental Origins of Disease, University Medical Center Utrecht, Utrecht, The Netherlands. N.Eijkelkamp@umcutrecht.nl" |
| DOI: | 10.1146/annurev-neuro-062012-170412 |
| ISSN/ISBN: | 1545-4126 (Electronic) 0147-006X (Linking) |
| Abstract: | "Transient receptor potential (TRP) channels act as sensors for a range of stimuli as diverse as light, sound, touch, pheromones, and tissue damage. Their role in mechanosensation in the animal kingdom, identified by gene ablation studies, has raised questions about whether they are directly mechanically gated, whether they act alone or in concert with other channels to transduce mechanical stimuli, and their relative importance in various functions and disease states in humans. The ability of these channels to form heteromultimers and interact with other ion channels underlies a range of cell-specific functions in different cell types. Here we overview recent advances in this rapidly expanding field, focusing on somatosensation, hearing, the cardiovascular system, and interactions between TRP channels and other proteins involved in mechanoelectrical signaling" |
| Keywords: | "Animals Humans Mechanoreceptors/*physiology Mechanotransduction, Cellular/*physiology Touch/*physiology Transient Receptor Potential Channels/*physiology;" |
| Notes: | "MedlineEijkelkamp, Niels Quick, Kathryn Wood, John N eng 20200/ARC_/Arthritis Research UK/United Kingdom BB/F000227/1/BB_/Biotechnology and Biological Sciences Research Council/United Kingdom G0901905/MRC_/Medical Research Council/United Kingdom WT_/Wellcome Trust/United Kingdom Research Support, Non-U.S. Gov't Review 2013/06/12 Annu Rev Neurosci. 2013 Jul 8; 36:519-46. doi: 10.1146/annurev-neuro-062012-170412" |
