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Genes Brain Behav

Title:		Sex differences in main olfactory system pathways involved in psychosexual function
Author(s):		Cherry JA; Baum MJ;
Address:		"Department of Psychological and Brain Sciences, Boston University, Boston, Massachusetts. Department of Biology, Boston University, Boston, Massachusetts"
Journal Title:		Genes Brain Behav
Year:		2020
Volume:		20191104
Issue:		2
Page Number:		e12618 -
DOI:		10.1111/gbb.12618
ISSN/ISBN:		1601-183X (Electronic) 1601-183X (Linking)
Abstract:		"We summarize literature from animal and human studies assessing sex differences in the ability of the main olfactory system to detect and process sex-specific olfactory signals ('pheromones') that control the expression of psychosexual functions in males and females. A case is made in non primate mammals for an obligatory role of pheromonal signaling via the main olfactory system (in addition to the vomeronasal-accessory olfactory system) in mate recognition and sexual arousal, with male-specific as well as female-specific pheromones subserving these functions in the opposite sex. Although the case for an obligatory role of pheromones in mate recognition and mating among old world primates, including humans, is weaker, we review the current literature assessing the role of putative human pheromones (eg, AND, EST, 'copulin'), detected by the main olfactory system, in promoting mate choice and mating in men and women. Based on animal studies, we hypothesize that sexually dimorphic effects of putative human pheromones are mediated via main olfactory inputs to the medial amygdala which, in turn, transmits olfactory information to sites in the hypothalamus that regulate reproduction"
Keywords:		Amygdala/metabolism Animals Brain/metabolism Female Humans Hypothalamus/metabolism Male Neurons/metabolism Odorants Olfactory Bulb/physiology Olfactory Pathways/*physiology Pheromones/*physiology Sex Attractants/metabolism Sex Characteristics Sexual Behav;
Notes:		"MedlineCherry, James A Baum, Michael J eng HD044897/National Institute of Child Health and Human Development/International HD21094/National Institute of Child Health and Human Development/International DC008962/DC/NIDCD NIH HHS/ Research Support, N.I.H., Extramural Review England 2019/10/22 Genes Brain Behav. 2020 Feb; 19(2):e12618. doi: 10.1111/gbb.12618. Epub 2019 Nov 4"