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Sci Total Environ

Title:		"Reproductive potential of mosquitofish is reduced by the masculinizing effect of a synthetic progesterone, gestodene: Evidence from morphology, courtship behaviour, ovary histology, sex hormones and gene expressions"
Author(s):		Chen S; Lin C; Tan J; Wang Y; Wang X; Wang X; Liu L; Li J; Hou L; Liu J; Leung JYS;
Address:		"School of Life Sciences, Guangzhou University, Guangzhou 510655, China. Ministry of Education Key Laboratory of Pollution Control and Ecological Remediation for Industrial Agglomeration Area, School of Environment and Energy, South China University of Technology, Guangzhou 510006, China. State Key Laboratory of Biocontrol, College of Ecology and Evolution, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China. School of Life Sciences, Guangzhou University, Guangzhou 510655, China. Electronic address: houliping7710@163.com. Key Laboratory of Water Quality and Conservation in the Pearl River Delta, Ministry of Education, Guangdong Provincial Key Laboratory of Radionuclides Pollution, China. Electronic address: liujuan858585@163.com. Faculty of Materials and Energy, Southwest University, Chongqing 400715, China; School of Biological Sciences, The University of Adelaide, Adelaide 5005, Australia. Electronic address: jonathan.leung@adelaide.edu.au"
Journal Title:		Sci Total Environ
Year:		2021
Volume:		20210118
Issue:
Page Number:		144570 -
DOI:		10.1016/j.scitotenv.2020.144570
ISSN/ISBN:		1879-1026 (Electronic) 0048-9697 (Linking)
Abstract:		"The ever-increasing use of synthetic hormones, especially progestins, for medical applications has drawn growing concerns due to their potential endocrine disrupting effects that may diminish the reproductive outputs of aquatic organisms. Using mosquitofish (Gambusia affinis) as a model species, we tested whether gestodene (GES), a commonly used progestin, can alter the expressions of genes associated with sex hormone synthesis and cause ensuing changes in morphological features, courtship behaviour and oocyte development. After exposing to GES at environmentally relevant concentrations (2.96, 32.9 and 354 ng L(-1)) for 40 days, we found that GES, especially at 354 ng L(-1), induced masculinization of female fish, indicated by the reduced body weight to length ratio and development of gonopodia (i.e. anal fins of male fish). Thus, the males showed less intimacy and mating interest towards the GES-exposed females, indicated by the reduced time spent on attending, following and mating behaviours. While oocyte development was seemingly unaffected by GES, spermatogonia were developed in the ovary. All the aforementioned masculinizing effects of GES were associated with the increased testosterone level and decreased estradiol level, driven by upregulating androgen receptor genes (Aralpha and Arbeta). Overall, our findings suggest that progestins could undermine the reproductive potential of aquatic organisms and hence their persistence in the progestin-contaminated environment"
Keywords:		"Animals Courtship *Cyprinodontiformes/genetics Female Gene Expression Gonadal Steroid Hormones Male Norpregnenes Ovary Progesterone *Water Pollutants, Chemical Courtship behaviour Endocrine disruption Gestodene Mosquitofish Sex hormone;"
Notes:		"MedlineChen, Shanduo Lin, Canyuan Tan, Jiefeng Wang, Yifan Wang, Xiaoyun Wang, Xiaolan Liu, Lu Li, Jiayi Hou, Liping Liu, Juan Leung, Jonathan Y S eng Netherlands 2021/01/25 Sci Total Environ. 2021 May 15; 769:144570. doi: 10.1016/j.scitotenv.2020.144570. Epub 2021 Jan 18"