| Title: | "Simple, quantitative headspace analysis by cryoadsorption on a short alumina PLOT column" |
| Address: | "Physical and Chemical Properties Division, National Institute of Standards and Technology, Boulder, CO, USA. bruno@boulder.nist.gov" |
| DOI: | 10.1093/chromsci/47.7.569 |
| ISSN/ISBN: | 0021-9665 (Print) 0021-9665 (Linking) |
| Abstract: | "The use of purge and trap methods for sampling volatile organic compounds prior to chromatographic analysis is a mature technology. Application to low volatility compounds has been far less facile and sensitive. Especially problematic has been applications that require precise quantitative analysis and analyses as a function of sample temperature, especially for low volatility analytes. In this paper, we have applied short lengths of alumina-coated PLOT columns as purge traps and operate the traps at low temperature during the collection cycles to improve efficiency in a method called cryoadsorption. We have applied the method as a function of temperature to a medium volatility solid, coumarin, as a demonstration, with further application to the pure explosive compound 2,4,6-trinitrotoluene (TNT) and the practical explosive C-4. We estimate that by use of mass spectrometry, the sampling method discussed in this paper can provide a detection limit of 0.0019 microg TNT per gram of substrate (determined with a 60 min sweep with the sample held at 60 degrees C). Moreover, for quantitative results, we can achieve a percent standard deviation (coefficient of variation) of 10% with samples as low as 0.064 microg TNT per gram of substrate" |
| Notes: | "PubMed-not-MEDLINEBruno, Thomas J eng 2009/09/24 J Chromatogr Sci. 2009 Aug; 47(7):569-74. doi: 10.1093/chromsci/47.7.569" |
