| Title: | The short-term treatment effects on the microbiota at the dorsum of the tongue in intra-oral halitosis patients--a randomized clinical trial |
| Author(s): | Ademovski SE; Persson GR; Winkel E; Tangerman A; Lingstrom P; Renvert S; |
| Address: | "Department of Oral Health Science, Section for Health and Society, Kristianstad University, Kristianstad, Sweden" |
| DOI: | 10.1007/s00784-012-0728-y |
| ISSN/ISBN: | 1436-3771 (Electronic) 1432-6981 (Linking) |
| Abstract: | "OBJECTIVES: This study aims to assess the effects of rinsing with zinc- and chlorhexidine-containing mouth rinse with or without adjunct tongue scraping on volatile sulfur compounds (VSCs) in breath air, and the microbiota at the dorsum of the tongue. MATERIAL AND METHODS: A randomized single-masked controlled clinical trial with a cross-over study design over 14 days including 21 subjects was performed. Bacterial samples from the dorsum of the tongue were assayed by checkerboard DNA-DNA hybridization. RESULTS: No halitosis (identified by VSC assessments) at day 14 was identified in 12/21 subjects with active rinse alone, in 10/21 with adjunct use of tongue scraper, in 1/21 for negative control rinse alone, and in 3/21 in the control and tongue scraping sequence. At day 14, significantly lower counts were identified only in the active rinse sequence (p < 0.001) for 15/78 species including, Fusobacterium sp., Porphyromonas gingivalis, Pseudomonas aeruginosa, Staphylococcus aureus, and Tannerella forsythia. A decrease in bacteria from baseline to day 14 was found in successfully treated subjects for 9/74 species including: P. gingivalis, Prevotella melaninogenica, S. aureus, and Treponema denticola. Baseline VSC scores were correlated with several bacterial species. The use of a tongue scraper combined with active rinse did not change the levels of VSC compared to rinsing alone. CONCLUSIONS: VSC scores were not associated with bacterial counts in samples taken from the dorsum of the tongue. The active rinse alone containing zinc and chlorhexidine had effects on intra-oral halitosis and reduced bacterial counts of species associated with malodor. Tongue scraping provided no beneficial effects on the microbiota studied. CLINICAL RELEVANCE: Periodontally healthy subjects with intra-oral halitosis benefit from daily rinsing with zinc- and chlorhexidine-containing mouth rinse" |
| Keywords: | "Adult Aged Anti-Infective Agents, Local/therapeutic use Bacteria/*drug effects Bacterial Load/drug effects Bacteroides/drug effects/isolation & purification Chlorhexidine/therapeutic use Cross-Over Studies Drug Combinations Female Follow-Up Studies Fusoba;" |
| Notes: | "MedlineAdemovski, Seida Erovic Persson, G Rutger Winkel, Edwin Tangerman, Albert Lingstrom, Peter Renvert, Stefan eng Comparative Study Randomized Controlled Trial Research Support, Non-U.S. Gov't Germany 2012/05/11 Clin Oral Investig. 2013 Mar; 17(2):463-73. doi: 10.1007/s00784-012-0728-y. Epub 2012 May 10" |
