| Title: | "HPLC Analysis and Risk Assessment of 15 Priority PAHs in Human Blood Serum of COPD Patient from Urban and Rural Areas, Iasi (Romania)" |
| Author(s): | Buculei I; Dobrin ME; Matei D; Onu I; Cioroiu IB; Caba B; Postelnicu MG; Buhociu DH; Musat CL; Crisan-Dabija R; Cernomaz AT; Trofor AC; |
| Address: | "Doctoral School, Faculty of Medicine, University of Medicine and Pharmacy 'Grigore T. Popa', 700115 Iasi, Romania. Clinical Hospital of Pulmonary Diseases, 700115 Iasi, Romania. Department of Biomedical Sciences, Faculty of Medical Bioengineering, University of Medicine and Pharmacy 'Grigore T. Popa', 700115 Iasi, Romania. Doctoral School of the Faculty of Chemical Engineering and Environmental Protection 'Cristofor Simionescu', Technical University 'Gheorghe Asachi', 700050 Iasi, Romania. Romanian Academy, Iasi Branch, Research Center for Oenology, 700505 Iasi, Romania. Department of Sports Games and Physical Education, Faculty of Physical Education and Sport, 'Dunarea de Jos' University of Galati, 800008 Galati, Romania. Doctoral School of Urban Planning, Ion Mincu' University of Architecture and Urban Planning, 010014 Bucharest, Romania. Department of Morphological and Functional Sciences, Faculty of Medicine and Pharmacy, 'Dunarea de Jos' University of Galati, 800008 Galati, Romania. Faculty of Medicine, University of Medicine and Pharmacy 'Grigore T. Popa', 700115 Iasi, Romania. Pulmonology Department, Clinic of Pulmonary Diseases, 700115 Iasi, Romania" |
| ISSN/ISBN: | 2075-4426 (Print) 2075-4426 (Electronic) 2075-4426 (Linking) |
| Abstract: | "One of the leading risk factors for environmental health problems is air pollution. The World Health Organization (WHO) reports that this risk factor is associated with one of every nine deaths worldwide. Epidemiological studies conducted in this field have shown a solid connection between respiratory pathology and polycyclic aromatic hydrocarbon (PAH) exposure. COPD and asthma are respiratory diseases that were shown to have a strong association with exposure to PAHs. The purpose of the present study was to assess the serum levels of 15 PAHs in 102 COPD patients and to evaluate the results according to the residence environment of the investigated subjects. Analyses were carried out using a high-performance liquid chromatograph Nexera X2-Shimadzu Japan, which was equipped with an LC-30AD pump and an SIL-30AC autosampler. Spiked matrices, procedure blanks, spiked controls, and calibration standards in the acetonitrile were used as quality-assurance samples. Benzo(a)pyrene is the main representative of PAHs and was determined in higher concentrations in subjects with COPD versus the control group from the urban area (0.90/0.47 ng/mL) and rural area (0.73/0.44 ng/mL). The values obtained for the Benzo(a)pyrene-equivalent factor indicate a higher carcinogenic potential for patients diagnosed with COPD in urban areas compared to those in rural areas. These results could be due to traffic and vehicle emissions. This research identifies the need for legislative action to decrease semi-volatile organic compounds, especially PAHs, mainly in urban cities, in order to improve environmental management and health conditions" |
| Keywords: | Copd PAHs air pollution chemical exposure risk assessment; |
| Notes: | "PublisherBuculei, Ioana Dobrin, Mona Elisabeta Matei, Daniela Onu, Ilie Cioroiu, Ionel Bogdan Caba, Bogdan Postelnicu, Madalina-Gabriela Buhociu, Dragos-Horia Musat, Carmina Liana Crisan-Dabija, Radu Cernomaz, Andrei Tudor Trofor, Antigona Carmen eng Switzerland 2023/09/28 J Pers Med. 2023 Aug 23; 13(9):1290. doi: 10.3390/jpm13091290" |
