| Title: | Mechanism of artemisinin phytotoxicity action: induction of reactive oxygen species and cell death in lettuce seedlings |
| Author(s): | Yan ZQ; Wang DD; Ding L; Cui HY; Jin H; Yang XY; Yang JS; Qin B; |
| Address: | "Key Laboratory of Chemistry of Northwestern Plant Resources of CAS and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China. College of Life Science, Northwest Normal University, Lanzhou 730070, China. Key Laboratory of Chemistry of Northwestern Plant Resources of CAS and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China; Key Laboratory of Tobacco Diseases and Insect Pests Monitoring Controlling and Integrated Management, Institute of Tobacco Research, Chinese Academy of Agricultural Sciences, Qingdao 266101, China. Key Laboratory of Chemistry of Northwestern Plant Resources of CAS and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China. Electronic address: bqin@licp.cas.cn" |
| DOI: | 10.1016/j.plaphy.2015.01.010 |
| ISSN/ISBN: | 1873-2690 (Electronic) 0981-9428 (Linking) |
| Abstract: | "Artemisinin has been recognized as an allelochemical that inhibits growth of several plant species. However, its mode of action is not well clarified. In this study, the mechanism of artemisinin phytotoxicity on lettuce seedlings was investigated. Root and shoot elongation of lettuce seedlings were inhibited by artemisinin in a concentration-dependent manner. The compound effectively arrested cell division and caused loss of cell viability in root tips of lettuce. Overproduction of reactive oxygen species (ROS) was induced by artemisinin. Lipid peroxidation, proline overproduction and reduction of chlorophyll content in lettuce seedlings were found after treatments. These results suggested that artemisinin could induce ROS overproduction, which caused membrane lipids peroxidation and cell death, and impacted mitosis and physiological processes, resulting in growth inhibition of receptor plants" |
| Keywords: | *Allelopathy Artemisia Artemisinins/*adverse effects *Cell Death Cell Membrane/metabolism Chlorophyll/metabolism Lettuce/*drug effects/growth & development/metabolism Lipid Peroxidation Meristem/metabolism Mitosis Pheromones/*metabolism Plant Roots/metabo; |
| Notes: | "MedlineYan, Zhi-Qiang Wang, Dan-Dan Ding, Lan Cui, Hai-Yan Jin, Hui Yang, Xiao-Yan Yang, Jian-She Qin, Bo eng Research Support, Non-U.S. Gov't France 2015/02/07 Plant Physiol Biochem. 2015 Mar; 88:53-9. doi: 10.1016/j.plaphy.2015.01.010. Epub 2015 Jan 30" |
