| Title: | Epimutational effects of electronic cigarettes |
| Author(s): | Yan R; Chen XL; Xu YM; Lau ATY; |
| Address: | "Laboratory of Cancer Biology and Epigenetics, Department of Cell Biology and Genetics, Shantou University Medical College, Shantou, Guangdong, 515041, People's Republic of China. Clinical Research Center, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, 515041, People's Republic of China. Laboratory of Cancer Biology and Epigenetics, Department of Cell Biology and Genetics, Shantou University Medical College, Shantou, Guangdong, 515041, People's Republic of China. amyymxu@stu.edu.cn. Clinical Research Center, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, 515041, People's Republic of China. amyymxu@stu.edu.cn. Laboratory of Cancer Biology and Epigenetics, Department of Cell Biology and Genetics, Shantou University Medical College, Shantou, Guangdong, 515041, People's Republic of China. andytylau@stu.edu.cn. Clinical Research Center, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, 515041, People's Republic of China. andytylau@stu.edu.cn" |
| Journal Title: | Environ Sci Pollut Res Int |
| DOI: | 10.1007/s11356-021-12985-9 |
| ISSN/ISBN: | 1614-7499 (Electronic) 0944-1344 (Linking) |
| Abstract: | "Electronic cigarettes (e-cigarettes), since they do not require tobacco combustion, have traditionally been considered less harmful than conventional cigarettes (c-cigarettes). In recent years, however, researchers have found many toxic compounds in the aerosols of e-cigarettes, and numerous studies have shown that e-cigarettes can adversely affect the human epigenome. In this review, we provide an update on recent findings regarding epigenetic outcomes of e-cigarette aerosols. Moreover, we discussed the effects of several typical e-cigarette ingredients (nicotine, tobacco-specific nitrosamines, volatile organic compounds, carbonyl compounds, and toxic metals) on DNA methylation, histone modifications, and noncoding RNA expression. These epigenetic effects could explain some of the diseases caused by e-cigarettes. It also reminds the public that like c-cigarettes, inhaling e-cigarette aerosols could also be accompanied with potential epigenotoxicity on the human body" |
| Keywords: | Aerosols *Electronic Nicotine Delivery Systems Humans Nicotine *Nitrosamines *Tobacco Products DNA methylation Electronic cigarettes Epigenetics Histone modifications ncRNA; |
| Notes: | "MedlineYan, Rui Chen, Xu-Li Xu, Yan-Ming Lau, Andy T Y eng 31771582/National Natural Science Foundation of China/ 31271445/National Natural Science Foundation of China/ 2017A030313131/Natural Science Foundation of Guangdong Province/ 2017KZDXM035/Basic and Applied Research Major Projects of Guangdong Province of China/ 2018KZDXM036/Basic and Applied Research Major Projects of Guangdong Province of China/ Andy T. Y. Lau-2016/'Yang Fan' Project of Guangdong Province of China/ Yan-Ming Xu-2015/'Yang Fan' Project of Guangdong Province of China/ Review Germany 2021/03/04 Environ Sci Pollut Res Int. 2021 Apr; 28(14):17044-17067. doi: 10.1007/s11356-021-12985-9. Epub 2021 Mar 2" |
