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J Biol Chem

Title:		Extracellular signal-regulated kinase 5 (ERK5) mediates prolactin-stimulated adult neurogenesis in the subventricular zone and olfactory bulb
Author(s):		Wang W; Pan YW; Wietecha T; Zou J; Abel GM; Kuo CT; Xia Z;
Address:		"Toxicology Program in the Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98195, USA"
Journal Title:		J Biol Chem
Year:		2013
Volume:		20121205
Issue:		4
Page Number:		2623 - 2631
DOI:		10.1074/jbc.M112.401091
ISSN/ISBN:		1083-351X (Electronic) 0021-9258 (Print) 0021-9258 (Linking)
Abstract:		"Prolactin-stimulated adult neurogenesis in the subventricular zone (SVZ) and olfactory bulb (OB) mediates several reproductive behaviors including mating/pregnancy, dominant male pheromone preference in females, and paternal recognition of offspring. However, downstream signaling mechanisms underlying prolactin-induced adult neurogenesis are completely unknown. We report here for the first time that prolactin activates extracellular signal-regulated kinase 5 (ERK5), a MAP kinase that is specifically expressed in the neurogenic regions of the adult mouse brain. Knockdown of ERK5 by retroviral infection of shRNA attenuates prolactin-stimulated neurogenesis in SVZ-derived adult neural stem/progenitor cells (aNPCs). Inducible erk5 deletion in adult neural stem cells of transgenic mice inhibits neurogenesis in the SVZ and OB following prolactin infusion or mating/pregnancy. These results identify ERK5 as a novel and critical signaling mechanism underlying prolactin-induced adult neurogenesis"
Keywords:		"Animals Brain/*metabolism Brain Mapping/methods Female Gene Deletion Genotype Mice Mice, Knockout Microscopy, Confocal/methods Mitogen-Activated Protein Kinase 7/metabolism/*physiology Neurogenesis Olfactory Bulb/*metabolism Prolactin/*metabolism Recombin;"
Notes:		"MedlineWang, Wenbin Pan, Yung-Wei Wietecha, Tomasz Zou, Junhui Abel, Glen M Kuo, Chay T Xia, Zhengui eng T32 HD007183/HD/NICHD NIH HHS/ F31 DC011216/DC/NIDCD NIH HHS/ R01 MH095840/MH/NIMH NIH HHS/ T32HD007183/HD/NICHD NIH HHS/ R01 NS078192/NS/NINDS NIH HHS/ MH095840/MH/NIMH NIH HHS/ F1DC011216/DC/NIDCD NIH HHS/ Research Support, N.I.H., Extramural 2012/12/12 J Biol Chem. 2013 Jan 25; 288(4):2623-31. doi: 10.1074/jbc.M112.401091. Epub 2012 Dec 5"