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World J Stem Cells

Title:		Effects of environmental stressors on stem cells
Author(s):		Worley JR; Parker GC;
Address:		"Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI 48202, United States. Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI 48202, United States. gparker@med.wayne.edu"
Journal Title:		World J Stem Cells
Year:		2019
Volume:		11
Issue:		9
Page Number:		565 - 577
DOI:		10.4252/wjsc.v11.i9.565
ISSN/ISBN:		1948-0210 (Print) 1948-0210 (Electronic) 1948-0210 (Linking)
Abstract:		"Environmental toxicants are ubiquitous, and many are known to cause harmful health effects. However, much of what we know or think we know concerning the targets and long-term effects of exposure to environmental stressors is sadly lacking. Toxicant exposure may have health effects that are currently mischaracterized or at least mechanistically incompletely understood. While much of the recent excitement about stem cells (SCs) focuses on their potential as therapeutic agents, they also offer a valuable resource to give us insight into the mechanisms and risks of toxicant effects. Not only as a response to the increasing ethical pressure to reduce animal testing, SC studies allow us valuable insight into the true effects of human exposure to environmental stressors under controlled conditions. We present a review of the history of publications on the effects of environmental stressors on SCs, followed by a consolidation of the literature over the past five years on a subset of key environmental stressors of importance to human health and their effects on both embryonic and tissue SCs. The review will make constructive suggestions as to areas of toxicant research where further studies are needed, as well as making indications of the potential utility for advancing knowledge and directing research on environmental toxicology"
Keywords:		Alcohols Endocrine disruptors Environmental substances Heavy Metals Ozone Particulate matter Stem cells Tobacco smoking Toxic Volatile organic compounds;
Notes:		"PubMed-not-MEDLINEWorley, Jessica R Parker, Graham C eng P30 ES020957/ES/NIEHS NIH HHS/ Review 2019/10/17 World J Stem Cells. 2019 Sep 26; 11(9):565-577. doi: 10.4252/wjsc.v11.i9.565"