| Title: | Expression profiling reveals differential gene induction underlying specific and non-specific memory for pheromones in mice |
| Author(s): | Upadhya SC; Smith TK; Brennan PA; Mychaleckyj JC; Hegde AN; |
| Address: | "Department of Neurobiology and Anatomy, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA" |
| DOI: | 10.1016/j.neuint.2011.08.009 |
| ISSN/ISBN: | 1872-9754 (Electronic) 0197-0186 (Print) 0197-0186 (Linking) |
| Abstract: | "Memory for the mating male's pheromones in female mice is thought to require synaptic changes in the accessory olfactory bulb (AOB). Induction of this memory depends on release of glutamate in response to pheromonal exposure coincident with release of norepinephrine (NE) in the AOB following mating. A similar memory for pheromones can also be induced artificially by local infusion of the GABA(A) receptor antagonist bicuculline into the AOB. The natural memory formed by exposure to pheromones during mating is specific to the pheromones sensed by the female during mating. In contrast, the artificial memory induced by bicuculline is non-specific and results in the female mice recognizing all pheromones as if they were from the mating male. Although protein synthesis has been shown to be essential for development of pheromone memory, the gene expression cascades critical for memory formation are not known. We investigated changes in gene expression in the AOB using oligonucleotide microarrays during mating-induced pheromone memory (MIPM) as well as bicuculline-induced pheromone memory (BIPM). We found the set of genes induced during MIPM and BIPM are largely non-overlapping and Ingenuity Pathway Analysis revealed that the signaling pathways in MIPM and BIPM also differ. The products of genes induced during MIPM are associated with synaptic function, indicating the possibility of modification at specific synapses, while those induced during BIPM appear to possess neuron-wide functions, which would be consistent with global cellular changes. Thus, these results begin to provide a mechanistic explanation for specific and non-specific memories induced by pheromones and bicuculline infusion respectively" |
| Keywords: | "Animals Female Gene Expression Profiling/*methods Gene Expression Regulation/*physiology Male Memory/*classification/*physiology Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred CBA Mice, Inbred DBA Sex Attractants/*physiology Transcriptional Acti;" |
| Notes: | "MedlineUpadhya, Sudarshan C Smith, Thuy K Brennan, Peter A Mychaleckyj, Josyf C Hegde, Ashok N eng T32 DC000057-08/DC/NIDCD NIH HHS/ BB/E020283/1/BB_/Biotechnology and Biological Sciences Research Council/United Kingdom T32 DC000057-07/DC/NIDCD NIH HHS/ T32 DC000057/DC/NIDCD NIH HHS/ Z01 DC000057/Intramural NIH HHS/ Comparative Study Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't England 2011/09/03 Neurochem Int. 2011 Nov; 59(6):787-803. doi: 10.1016/j.neuint.2011.08.009. Epub 2011 Aug 23" |
