« Previous AbstractAdvances in Smoking Related In Vitro Inhalation Toxicology: A Perspective Case of Challenges and Opportunities from Progresses in Lung-on-Chip Technologies    Next AbstractIntraspecies Volatile Interactions Affect Growth Rates and Exometabolomes in Aspergillus oryzae KCCM 60345 »

Crit Rev Food Sci Nutr

Title:		"Black tea: Phytochemicals, cancer chemoprevention, and clinical studies"
Author(s):		Singh BN; Rawat AK; Bhagat RM; Singh BR;
Address:		"a Pharmacognosy & Ethnopharmacology Division, CSIR-National Botanical Research Institute , Lucknow , UP , India. b Biochemistry Department , Tocklai Experimental Station, Tea Research Association , Jorhat , Assam , India. c Soil Department , Tocklai Experimental Station, Tea Research Association , Jorhat , Assam , India. d Center of Excellence in Materials Science (Nanomaterials), Z. H. College of Engineering & Technology, Aligarh Muslim University , Aligarh , UP , India"
Journal Title:		Crit Rev Food Sci Nutr
Year:		2017
Volume:		57
Issue:		7
Page Number:		1394 - 1410
DOI:		10.1080/10408398.2014.994700
ISSN/ISBN:		1549-7852 (Electronic) 1040-8398 (Linking)
Abstract:		"Tea (Camellia sinensis L.) is the most popular, flavored, functional, and therapeutic non-alcoholic drink consumed by two-thirds of the world's population. Black tea leaves are reported to contain thousands of bioactive constituents such as polyphenols, amino acids, volatile compounds, and alkaloids that exhibit a range of promising pharmacological properties. Due to strong antioxidant property, black tea inhibits the development of various cancers by regulating oxidative damage of biomolecules, endogenous antioxidants, and pathways of mutagen and transcription of antioxidant gene pool. Regular drinking of phytochemicals-rich black tea is linked to regulate several molecular targets, including COX-2, 5-LOX, AP-1, JNK, STAT, EGFR, AKT, Bcl2, NF-kappaB, Bcl-xL, caspases, p53, FOXO1, TNFalpha, PARP, and MAPK, which may be the basis of how dose of black tea prevents and cures cancer. In vitro and preclinical studies support the anti-cancer activity of black tea; however, its effect in human trails is uncertain, although more clinical experiments are needed at molecular levels to understand its anti-cancer property. This review discusses the current knowledge on phytochemistry, chemopreventive activity, and clinical applications of black tea to reveal its anti-cancer effect"
Keywords:		"Amino Acids/analysis/pharmacology Animals Antimutagenic Agents/analysis/pharmacology Antineoplastic Agents/analysis/pharmacology Antioxidants/analysis/pharmacology Catechin/analysis/pharmacology Cell Line, Tumor *Chemoprevention Clinical Studies as Topic;"
Notes:		"MedlineSingh, Brahma N Rawat, A K S Bhagat, R M Singh, B R eng Review 2015/11/13 Crit Rev Food Sci Nutr. 2017 May 3; 57(7):1394-1410. doi: 10.1080/10408398.2014.994700"