| Title: | Decreases in urinary pheromonal activities in male mice after exposure to 3-methylchoranthrene |
| Author(s): | Shiraiwa T; Kamiyama N; Kashiwayanagi M; |
| Address: | "Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan" |
| DOI: | 10.1016/j.toxlet.2006.12.010 |
| ISSN/ISBN: | 0378-4274 (Print) 0378-4274 (Linking) |
| Abstract: | "Many classes of environmental pollutants, which are found at significant levels in the environment, affect the reproductive functions. The gonadal functions of various animals are regulated by pheromones excreted from mating partners. Pheromones in male urine play essential roles in the sexual maturation of female mice. Pheromones are received by sensory neurons in the vomeronasal organ, which innervate to the accessory olfactory bulb (AOB). The effects of a typical aromatic environmental pollutant (3-methylchoranthrene) on excretion of pheromones from male mice were explored based on neuronal Fos responses of the AOB of female mice. On days 1 and 3 after intraperitoneal administration of 3-methylchoranthrene (3-MC), the density of Fos-immunoreactive (Fos-ir) cells in the AOB of female mice after exposure to urine excreted from the administered males was lower than that after exposure to urine from non-administered males. These results suggest that 3-MC blocks chemical communication from male to female mice by reducing pheromonal activities" |
| Keywords: | "Air Pollutants/*toxicity Animals Female Immunohistochemistry Male Methylcholanthrene/*toxicity Mice Mice, Inbred C3H Olfactory Bulb/metabolism Proteins/metabolism Proto-Oncogene Proteins c-fos/biosynthesis Sex Attractants/*urine Vomeronasal Organ/drug eff;" |
| Notes: | "MedlineShiraiwa, Takeshi Kamiyama, Naoya Kashiwayanagi, Makoto eng Netherlands 2007/02/06 Toxicol Lett. 2007 Mar 8; 169(2):137-44. doi: 10.1016/j.toxlet.2006.12.010. Epub 2007 Jan 8" |
