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Wellcome Open Res

Title:		Case Report: The effect of intravenous and oral antibiotics on the gut microbiome and breath volatile organic compounds over one year
Author(s):		Shahi F; Forrester S; Redeker K; Chong JPJ; Barlow G;
Address:		"Department of Biology, University of York, UK, York, YO10 5DD, UK. Department of Infection, Hull University Teaching Hospitals NHS Trust, Hull, HU3 2JZ, UK. Experimental Medicine and Biomedicine, Hull York Medical School, University of York, York, YO10 5DD, UK"
Journal Title:		Wellcome Open Res
Year:		2022
Volume:		20221205
Issue:
Page Number:		50 -
DOI:		10.12688/wellcomeopenres.17450.3
ISSN/ISBN:		2398-502X (Print) 2398-502X (Electronic) 2398-502X (Linking)
Abstract:		"BACKGROUND: Antimicrobial resistance (AMR) is a global concern and better understanding of the gut microbiome, a known 'amplifier' of AMR, may allow future clinicians to tailor therapy to minimise this risk and offer a personalised medicine approach. To examine the gut microbiome, patients are required to provide faecal samples; more convenient and cheaper solutions need to be found. METHODS: As part of a pilot study looking at how routes of administration affect the gut microbiome in NHS patients undergoing routine clinical management for infections, we hypothesised that effects on the gut microbiome varied with the route and metabolism of antibiotic used, and these changes may be reflected in breath metabolites. We present a case report of a patient with an unusual clinical history, alongside breath metabolite and gut microbiome data taken before, during and after antibiotic therapy over a period of one year. RESULTS: We noted a shift in the dominant Bacteroides strain in the patient's gut microbiome between pre- and post-therapy samples, along with an alteration in the composition of breath metabolites. CONCLUSIONS: This study provides a framework for similar future work and highlights the need for further research on the relationships between changes in microbial gut communities and antimicrobial exposure, patient clinical status, and the metabolites of human breath"
Keywords:		antibiotics antimicrobials breath metabolites microbiome resistance volatile organic compounds;
Notes:		"PubMed-not-MEDLINEShahi, Farah Forrester, Sarah Redeker, Kelly Chong, James P J Barlow, Gavin eng Case Reports England 2023/03/08 Wellcome Open Res. 2022 Dec 5; 7:50. doi: 10.12688/wellcomeopenres.17450.3. eCollection 2022"