« Previous AbstractBiomarker measurements of concurrent exposure to multiple environmental chemicals and chemical classes in children    Next AbstractDe novo biosynthesis of the aggregation pheromone components ipsenol and ipsdienol by the pine bark beetles Ips paraconfusus Lanier and Ips pini (Say) (Coleoptera: Scolytidae) »

Proc Jpn Acad Ser B Phys Biol Sci

Title:		Novel function of lipids as a pheromone from the Harderian gland of golden hamster
Author(s):		Seyama Y; Uchijima Y;
Address:		"Visiting Professor, National Institution for Academic Degrees and University Evaluation, Tokyo, Japan"
Journal Title:		Proc Jpn Acad Ser B Phys Biol Sci
Year:		2007
Volume:		83
Issue:		3
Page Number:		77 - 96
DOI:		10.2183/pjab.83.77
ISSN/ISBN:		0386-2208 (Print) 1349-2896 (Electronic) 0386-2208 (Linking)
Abstract:		"Sexual diversity of ADG in Harderian gland of golden hamster was demonstrated on TLC. Female ADG contained iso- and anteiso-branched acyl and alkyl components, but male ADG contained only straight chain ones, which suggested the hormonal control of the expression of acyl-CoA dehydrogenases in the catabolism of BCAA. Acyl-CoA dehydrogenases were not expressed in the absence of testosterone, and then isovaleryl-CoA, 2-methylbutyryl-CoA, and isobutyryl-CoA accumulated, and acted as primers for the synthesis of iso- and anteiso-branched fatty acids. The incorporation of [U-(14)C] leucine into lipids was monitored by TLC. The cholesterol fraction was labeled in males but not in female, which means that cholesterol was not produced from BCAA in female gland due to the lack of expression of acyl-CoA dehydrogenases. We monitored the behavior of male hamsters toward female gland lipids, and found slightly greater attractiveness in female ones than that in male ones although the difference was not significant. Considering the lifestyle of golden hamster in nature, we propose a hypothesis that the lipids from the Harderian gland of golden hamster serve as a pheromone to declare their territory and to seek the mate with good congeniality"
Keywords:		Harderian gland acyl-CoA dehydrogenase androgen receptor golden hamster pheromone sexual dimorphism;
Notes:		"PubMed-not-MEDLINESeyama, Yousuke Uchijima, Yasunobu eng Review Japan 2007/05/01 Proc Jpn Acad Ser B Phys Biol Sci. 2007 May; 83(3):77-96. doi: 10.2183/pjab.83.77"