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Environ Res

Title:		Influence of the environmental relative humidity on the inflammatory response of skin model after exposure to various environmental pollutants
Author(s):		Seurat E; Verdin A; Cazier F; Courcot D; Fitoussi R; Vie K; Desauziers V; Momas I; Seta N; Achard S;
Address:		"Laboratoire de Sante Publique et Environnement, Hera 'Health Environmental Risk Assessment', Inserm UMR1153-CRESS (Centre de Recherche en Epidemiologie et StatistiqueS), Universite de Paris, Faculte de Pharmacie de Paris, 4, Avenue de L'Observatoire, 75006, Paris, France. Unite de Chimie Environnementale et Interactions sur le Vivant UR4492, SFR Condorcet FR CNRS 3417, Maison de La Recherche en Environnement Industriel 2, Universite Du Littoral Cote D'Opale, 189A Avenue Maurice Schumann, 59140, Dunkerque, France. Centre Commun de Mesures (CCM), Universite Du Littoral-Cote D'Opale, 145 Avenue Maurice Schumann, 5914, Dunkerque, France. Laboratoires Clarins, 5 Rue Ampere, 95300, Pontoise, France. IPREM, IMT Mines Ales, Universite de Pau et des Pays de L'Adour, E2S UPPA, CNRS, Pau, France. Laboratoire de Sante Publique et Environnement, Hera 'Health Environmental Risk Assessment', Inserm UMR1153-CRESS (Centre de Recherche en Epidemiologie et StatistiqueS), Universite de Paris, Faculte de Pharmacie de Paris, 4, Avenue de L'Observatoire, 75006, Paris, France. Electronic address: sophie.achard@u-paris.fr"
Journal Title:		Environ Res
Year:		2021
Volume:		20201102
Issue:
Page Number:		110350 -
DOI:		10.1016/j.envres.2020.110350
ISSN/ISBN:		1096-0953 (Electronic) 0013-9351 (Linking)
Abstract:		"The skin is an essential barrier, protecting the body against the environment and its numerous pollutants. Several environmental pollutants are known to affect the skin, inducing premature aging through mechanisms including oxidative stress, inflammation, and impairment of skin functions. Even climate conditions can impact the skin. Therefore, using a Reconstructed Human Epidermis (RHE), we tested the effect of two samples of fine particulate matters (PM(0.3-2.5) - one metals-rich sample and the other organic compounds-rich), two Volatile Organic Compounds mixtures (VOCs - from a solvent-based paint and a water-based paint) and Tobacco Smoke (TS). All pollutants affected cellular functionality, but to a lesser extent for the water-based paint VOC. This effect was enhanced when RHE were preconditioned for 2 h by a semi-dry airflow (45% relative humidity) before pollutants application, compared to preconditioning by a humid airflow (90% relative humidity). In the absence of preconditioning, IL-1alpha, IL-6, IL-8, and RANTES were almost systematically induced by pollutants. When RHE were preconditioned by a semi-dry or humid airflow before being subjected to pollutants, the increase of IL-1alpha, IL-8, and RANTES falls into two groups. Similarly to RHE not treated with pollutants, RHE treated with VOCs after preconditioning by a semi-dry airflow showed increased IL-1alpha, IL-8, and RANTES release. On the contrary, RHE treated with PM or TS after preconditioning by a semi-dry airflow show a lower increase in IL-1alpha, IL-8, and RANTES compared to preconditioning by a humid airflow. The effect of real environmental relative humidity conditions of the air, combined with acute exposure to various environmental pollutants, seemed to relate mainly to structural changes of the skin, determining the outcome of the inflammatory response depending on the physicochemical characteristics of pollutants"
Keywords:		*Air Pollutants/analysis/toxicity *Environmental Pollutants/toxicity Humans Humidity Particulate Matter/analysis/toxicity *Volatile Organic Compounds/analysis/toxicity 3D-skin model Air liquid exposure Environmental humidity Environmental pollutants Infla;
Notes:		"MedlineSeurat, Emeline Verdin, Anthony Cazier, Fabrice Courcot, Dominique Fitoussi, Richard Vie, Katell Desauziers, Valerie Momas, Isabelle Seta, Nathalie Achard, Sophie eng Research Support, Non-U.S. Gov't Netherlands 2020/11/05 Environ Res. 2021 May; 196:110350. doi: 10.1016/j.envres.2020.110350. Epub 2020 Nov 2"