| Title: | Direct Synthesis of Acyl Fluorides from Carboxylic Acids with the Bench-Stable Solid Reagent (Me(4)N)SCF(3) |
| Author(s): | Scattolin T; Deckers K; Schoenebeck F; |
| Address: | "Institute of Organic Chemistry, RWTH Aachen University , Landoltweg 1, 52074 Aachen, Germany" |
| DOI: | 10.1021/acs.orglett.7b02516 |
| ISSN/ISBN: | 1523-7052 (Electronic) 1523-7052 (Linking) |
| Abstract: | "A convenient, highly efficient, and selective transformation of aliphatic and aromatic carboxylic acids to acyl fluorides is reported. In contrast to established approaches that require toxic or volatile additives and base and reaction control (i.e., cooling, slow addition), this protocol allows for a straightforward access to various R-COF entities upon direct reaction with the bench-stable, solid reagent (Me(4)N)SCF(3) at room temperature. The method is base- and additive-free, compatible with late-stage synthetic applications, high functional group tolerance, and facile target compound purification via filtration" |
| Notes: | "PubMed-not-MEDLINEScattolin, Thomas Deckers, Kristina Schoenebeck, Franziska eng 2017/10/13 Org Lett. 2017 Nov 3; 19(21):5740-5743. doi: 10.1021/acs.orglett.7b02516" |
