Bedoukian   RussellIPM   RussellIPM   Piezoelectric Micro-Sprayer


Home
Animal Taxa
Plant Taxa
Semiochemicals
Floral Compounds
Semiochemical Detail
Semiochemicals & Taxa
Synthesis
Control
Invasive spp.
References

Abstract

Guide

Alphascents
Pherobio
InsectScience
E-Econex
Counterpart-Semiochemicals
Print
Email to a Friend
Kindly Donate for The Pherobase

« Previous AbstractEpimerisation of chiral hydroxylactones by short-chain dehydrogenases/reductases accounts for sex pheromone evolution in Nasonia    Next AbstractMonitoring of occupational exposure to volatile organohalogen solvents (VOXs) in human urine samples of dry-cleaner workers by TLHS-DAI-GC-ECD procedure »

Front Microbiol


Title:Nutrient and Stress Sensing in Pathogenic Yeasts
Author(s):Rutherford JC; Bahn YS; van den Berg B; Heitman J; Xue C;
Address:"Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, United Kingdom. Department of Biotechnology, Yonsei University, Seoul, South Korea. Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, United States. Public Health Research Institute, Rutgers University, Newark, NJ, United States. Department of Molecular Genetics, Biochemistry and Microbiology, Rutgers University, Newark, NJ, United States"
Journal Title:Front Microbiol
Year:2019
Volume:20190308
Issue:
Page Number:442 -
DOI: 10.3389/fmicb.2019.00442
ISSN/ISBN:1664-302X (Print) 1664-302X (Electronic) 1664-302X (Linking)
Abstract:"More than 1.5 million fungal species are estimated to live in vastly different environmental niches. Despite each unique host environment, fungal cells sense certain fundamentally conserved elements, such as nutrients, pheromones and stress, for adaptation to their niches. Sensing these extracellular signals is critical for pathogens to adapt to the hostile host environment and cause disease. Hence, dissecting the complex extracellular signal-sensing mechanisms that aid in this is pivotal and may facilitate the development of new therapeutic approaches to control fungal infections. In this review, we summarize the current knowledge on how two important pathogenic yeasts, Candida albicans and Cryptococcus neoformans, sense nutrient availability, such as carbon sources, amino acids, and ammonium, and different stress signals to regulate their morphogenesis and pathogenicity in comparison with the non-pathogenic model yeast Saccharomyces cerevisiae. The molecular interactions between extracellular signals and their respective sensory systems are described in detail. The potential implication of analyzing nutrient and stress-sensing systems in antifungal drug development is also discussed"
Keywords:G protein-coupled receptor Mep2 Tor fungal pathogen nutrient sensing stress response transceptor yeast;
Notes:"PubMed-not-MEDLINERutherford, Julian C Bahn, Yong-Sun van den Berg, Bert Heitman, Joseph Xue, Chaoyang eng R01 AI050113/AI/NIAID NIH HHS/ R01 AI123315/AI/NIAID NIH HHS/ R37 AI039115/AI/NIAID NIH HHS/ Review Switzerland 2019/04/02 Front Microbiol. 2019 Mar 8; 10:442. doi: 10.3389/fmicb.2019.00442. eCollection 2019"

 
Back to top
 
Citation: El-Sayed AM 2024. The Pherobase: Database of Pheromones and Semiochemicals. <http://www.pherobase.com>.
© 2003-2024 The Pherobase - Extensive Database of Pheromones and Semiochemicals. Ashraf M. El-Sayed.
Page created on 27-12-2024