| Title: | Lower COVID-19 mortality in Italian forested areas suggests immunoprotection by Mediterranean plants |
| Address: | "Department of Chemical, Materials and Industrial Production Engineering (DICMaPI), University of Naples Federico II, Piazzale V. Tecchio 80, 80125 Naples, Italy. GRID: grid.4691.a. ISNI: 0000 0001 0790 385X Istituto Di Biostrutture E Bioimmagini IBB - CNR, Via Mezzocannone 16, 80134 Naples, Italy. GRID: grid.429699.9. ISNI: 0000 0004 1790 0507" |
| DOI: | 10.1007/s10311-020-01063-0 |
| ISSN/ISBN: | 1610-3653 (Print) 1610-3661 (Electronic) 1610-3653 (Linking) |
| Abstract: | "The COVID-19 pandemic has induced dramatic effects on the population of the industrialized north of Italy, whereas it has not heavily affected inhabitants of the southern regions. This might be explained in part by human exposure to high levels of fine particulate matter (PM) in the air of northern Italy, thus exacerbating the mortality. Since trees mitigate air pollution by intercepting PM onto plant surfaces and bolster the human immune system by emitting bioactive volatile organic compounds (VOCs), we hypothesize a protective role of evergreen forested areas in southern Italy. We compared the mortality rate due to COVID-19, the death number, the positivity rate and the forest coverage per capita in various Italian regions. Hectares of forest per capita and prevalence of deciduous versus evergreen forestal species were also estimated. In silico docking studies of potentially protective compounds found in Laurus nobilis L., a typical Mediterranean plant, were performed to search for potential antivirals. We found that the pandemic's severity was generally lower in southern regions, especially those with more than 0.3 hectares of forest per capita. The lowest mortality rates were found in southern Italy, mainly in regions like Molise (0.007%) and Basilicata (0.005%) where the forest per capita ratio is higher than 0.5 Ha/person. Our findings suggest that evergreen Mediterranean forests and shrubland plants could have protected the southern population by emission of immuno-modulating VOCs and provision of dietary sources of bioactive compounds. Moreover, in silico studies revealed a potential anti-COVID-19 activity in laurusides, which are unexplored glycosides from bay laurel. Overall, our results highlight the importance of nature conservation and applications to the search for natural antivirals" |
| Keywords: | Air pollution Covid-19 Forest bathing Laurus nobilis Mediterranean vegetation Mpro inhibitors Particulate matter Plant therapeutics Plant toxicity SARS-CoV-2; |
| Notes: | "PubMed-not-MEDLINERoviello, Valentina Roviello, Giovanni N eng 2020/08/25 Environ Chem Lett. 2021; 19(1):699-710. doi: 10.1007/s10311-020-01063-0. Epub 2020 Aug 14" |
