« Previous Abstract"Levels and distribution of dissolved hydrophobic organic contaminants in the Morava river in Zlin district, Czech Republic as derived from their accumulation in silicone rubber passive samplers"    Next AbstractEthnic/racial and genetic influences on cerumen odorant profiles »

J Chromatogr B Analyt Technol Biomed Life Sci

Title:		Identification of volatile organic compounds in human cerumen
Author(s):		Prokop-Prigge KA; Thaler E; Wysocki CJ; Preti G;
Address:		"Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA. Electronic address: kprigge@monell.org. Department of Otorhinolaryngology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA; School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA; Department of Dermatology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA"
Journal Title:		J Chromatogr B Analyt Technol Biomed Life Sci
Year:		2014
Volume:		20140205
Issue:
Page Number:		48 - 52
DOI:		10.1016/j.jchromb.2014.01.043
ISSN/ISBN:		1873-376X (Electronic) 1570-0232 (Print) 1570-0232 (Linking)
Abstract:		"We report here the initial examination of volatile organic compounds (VOCs) emanating from human earwax (cerumen). Recent studies link a single nucleotide polymorphism (SNP) in the adenosine triphosphate (ATP) binding cassette, sub-family C, member 11 gene (ABCC11) to the production of different types of axillary odorants and cerumen. ABCC11 encodes an ATP-driven efflux pump protein that plays an important function in ceruminous apocrine glands of the auditory canal and the secretion of axillary odor precursors. The type of cerumen and underarm odor produced by East Asians differ markedly from that produced by non-Asians. In this initial report we find that both groups emit many of the same VOCs but differ significantly in the amounts produced. The principal odorants are volatile organic C2-to-C6 acids. The physical appearance of cerumen from the two groups also matches previously reported ethnic differences, viz., cerumen from East Asians appears dry and white while that from non-Asians is typically wet and yellowish-brown"
Keywords:		Adult Asian People Cerumen/*chemistry Female Gas Chromatography-Mass Spectrometry/methods Humans Male Solid Phase Microextraction Volatile Organic Compounds/*analysis/chemistry White People Axillary odor Cerumen Earwax Gc/ms Spme Volatile organic compound;
Notes:		"MedlineProkop-Prigge, Katharine A Thaler, Erica Wysocki, Charles J Preti, George eng T32 DC000014/DC/NIDCD NIH HHS/ 5T32DC0014/DC/NIDCD NIH HHS/ Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Netherlands 2014/02/28 J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Mar 15; 953-954:48-52. doi: 10.1016/j.jchromb.2014.01.043. Epub 2014 Feb 5"