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Angew Chem Int Ed Engl

Title:		Biosynthesis of Modular Ascarosides in C. elegans
Author(s):		Panda O; Akagi AE; Artyukhin AB; Judkins JC; Le HH; Mahanti P; Cohen SM; Sternberg PW; Schroeder FC;
Address:		"Boyce Thompson Institute and Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, USA. Howard Hughes Medical Institute and Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA"
Journal Title:		Angew Chem Int Ed Engl
Year:		2017
Volume:		20170328
Issue:		17
Page Number:		4729 - 4733
DOI:		10.1002/anie.201700103
ISSN/ISBN:		1521-3773 (Electronic) 1433-7851 (Print) 1433-7851 (Linking)
Abstract:		"The nematode Caenorhabditis elegans uses simple building blocks from primary metabolism and a strategy of modular assembly to build a great diversity of signaling molecules, the ascarosides, which function as a chemical language in this model organism. In the ascarosides, the dideoxysugar ascarylose serves as a scaffold to which diverse moieties from lipid, amino acid, neurotransmitter, and nucleoside metabolism are attached. However, the mechanisms that underlie the highly specific assembly of ascarosides are not understood. We show that the acyl-CoA synthetase ACS-7, which localizes to lysosome-related organelles, is specifically required for the attachment of different building blocks to the 4'-position of ascr#9. We further show that mutants lacking lysosome-related organelles are defective in the production of all 4'-modified ascarosides, thus identifying the waste disposal system of the cell as a hotspot for ascaroside biosynthesis"
Keywords:		Animals *Biosynthetic Pathways Caenorhabditis elegans/chemistry/*metabolism Caenorhabditis elegans Proteins/*metabolism Coenzyme A Ligases/*metabolism Glycolipids/chemistry/*metabolism Hexoses/chemistry/*metabolism Lysosomes/metabolism biosynthesis chemic;
Notes:		"MedlinePanda, Oishika Akagi, Allison E Artyukhin, Alexander B Judkins, Joshua C Le, Henry H Mahanti, Parag Cohen, Sarah M Sternberg, Paul W Schroeder, Frank C eng T32 GM007616/GM/NIGMS NIH HHS/ P40 OD010440/OD/NIH HHS/ R01 GM113692/GM/NIGMS NIH HHS/ T32 GM008500/GM/NIGMS NIH HHS/ R01 GM088290/GM/NIGMS NIH HHS/ HHMI/Howard Hughes Medical Institute/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Germany 2017/04/04 Angew Chem Int Ed Engl. 2017 Apr 18; 56(17):4729-4733. doi: 10.1002/anie.201700103. Epub 2017 Mar 28"